Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:150759
Lallemand Y, et al., Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol. 2009 Jul 15;331(2):189-98
|
|
Assay type:
|
RNA in situ
|
|
MGI Accession ID:
|
MGI:6404387
|
|
Gene symbol:
|
Msx1
|
|
Gene name:
|
msh homeobox 1
|
|
|
Results
|
Specimen
1A:
embryonic day 11.5
(more  )
Specimen
1A:
(close  )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
1B:
(close )
|
Genetic Background:
|
involves: 101/H * C3H/HeH * CBA/H
|
|
Mutant Allele(s):
|
Gli3Xt/Gli3Xt
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: forelimb bud |
Present |
Regionally restricted |
1B
|
Expression reduced in anterior domain, more limited for Msx1 than for Msx2. Apical and posterior domains were not affected.
|
Specimen
1E:
embryonic day 11.5
(more )
Specimen
1E:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
1F:
embryonic day 11.5; Rr29Hx/Rr29 +
(more )
Specimen
1F:
(close )
|
Genetic Background:
|
involves: C57BL/10SnJ * DBA/2J
|
|
Mutant Allele(s):
|
Rr29Hx/Rr29+
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: forelimb bud |
Present |
Regionally restricted |
1F
|
Expression reduced in anterior-most region where Shh is ectopically expressed.
|
Specimen
1I:
embryonic day 10.75
(more )
Specimen
1I:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 10.75
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS18: forelimb bud |
Present |
Regionally restricted |
1I
|
Expression lower in central domain of limb bud.
|
Specimen
1J:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ
|
|
Mutant Allele(s):
|
Shhtm1Amc/Shhtm1Amc
|
|
Age:
|
embryonic day 10.75
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS18: forelimb bud |
Present |
Regionally restricted |
1J
|
Expression in central region significantly higher than in controls.
|
Specimen
1M:
embryonic day 11.5
(more )
Specimen
1M:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
1N:
(close )
|
Genetic Background:
|
involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * CBA/H
|
|
Mutant Allele(s):
|
Gli3Xt/Gli3Xt
Shhtm1Amc/Shhtm1Amc
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: forelimb bud |
Present |
Regionally restricted |
1N
|
Slight anterior dowregulation of expression compared to control - identical to that observed with single Gli3-/- mutant.
|
Specimen
S1A:
embryonic day 11.5
(more )
Specimen
S1A:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
S1B:
(close )
|
Genetic Background:
|
involves: 101/H * C3H/HeH * CBA/H
|
|
Mutant Allele(s):
|
Gli3Xt/Gli3Xt
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: hindlimb bud |
Present |
Regionally restricted |
S1B
|
Expression reduced anteriorly, more limited for Msx1 than for Msx2. Apical and posterior domains were not affected.
|
Specimen
S1E:
embryonic day 11.5
(more )
Specimen
S1E:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
S1F:
embryonic day 11.5; Rr29Hx/Rr29 +
(more )
Specimen
S1F:
(close )
|
Genetic Background:
|
involves: C57BL/10SnJ * DBA/2J
|
|
Mutant Allele(s):
|
Rr29Hx/Rr29+
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: hindlimb bud |
Present |
Regionally restricted |
S1F
|
Expression reduced in anterior-most region where Shh is ectopically expressed.
|
Specimen
S1I:
embryonic day 10.75
(more )
Specimen
S1I:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 10.75
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS18: hindlimb bud |
Present |
Regionally restricted |
S1I
|
Expression lower in central domain of limb bud.
|
Specimen
S1J:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ
|
|
Mutant Allele(s):
|
Shhtm1Amc/Shhtm1Amc
|
|
Age:
|
embryonic day 10.75
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS18: hindlimb bud |
Present |
Regionally restricted |
S1J
|
Expression levels significanly higher than in controls.
|
Specimen
S1M:
embryonic day 11.5
(more )
Specimen
S1M:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
S1N:
(close )
|
Genetic Background:
|
involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * CBA/H
|
|
Mutant Allele(s):
|
Gli3Xt/Gli3Xt
Shhtm1Amc/Shhtm1Amc
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: hindlimb bud |
Present |
Regionally restricted |
S1N
|
Slight anterior downregulation of expression compared to control, identical to that observed with single Gli3-/- mutant.
|
|
Analysis Tools