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Gene Expression Data
Assay Details
Assay
Reference: J:280426 Matoba S, et al., Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21047-21053
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6403481
Gene symbol: Slc38a4
Gene name: solute carrier family 38, member 4
Antibody: anti-SNAT (sc-376664; H-9)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 3A - E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: spongiotrophoblast Present 3A E10.5 , 3A E10.5 ST
TS17: labyrinthine zone Present 3A E10.5 , 3A E10.5 LB Highest expression is seen in the chorionic basal trophoblasts. It is also seen at the maternal-fetal interface.
Specimen 3A - E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: spongiotrophoblast Present 3A E11.5 ST , 3A E11.5
TS19: labyrinthine zone Present 3A E11.5 LB , 3A E11.5 Highest expression is seen in the chorionic basal trophoblasts. It is also seen at the maternal-fetal interface.
Specimen 3A - E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: spongiotrophoblast Present 3A E13.5 ST , 3A E13.5
TS21: labyrinthine zone Present 3A E13.5 , 3A E13.5 LB Highest expression is seen in the chorionic basal trophoblasts. It is also seen at the maternal-fetal interface.
Specimen 3A - E19.5: embryonic day 19.5 (more )
Structure Level Pattern Image Note
TS26: spongiotrophoblast Weak 3A E19.5 , 3A E19.5 ST
TS26: labyrinthine zone Present 3A E19.5 LB , 3A E19.5 Expression is seen at the maternal-fetal interface. Levels have diminished in the chorionic basal trophoblasts.
Specimen 3B - WT: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: ectoplacental cone Present 3B WT , 3B WT inset
TS13: chorionic plate Present 3B WT
Specimen 3B - MKO: embryonic day 8.5; Slc38a4em#Smtb/Slc38a4+ (more )
Note: maternal inheritance of knockout allele
Structure Level Pattern Image Note
TS13: ectoplacental cone Present 3B MKO , 3B MKO inset
TS13: chorionic plate Present 3B MKO
Specimen 3B - PKO: embryonic day 8.5; Slc38a4em#Smtb/Slc38a4+ (more )
Note: paternal inheritance of knockout allele
Structure Level Pattern Image Note
TS13: ectoplacental cone Present Single cells 3B PKO inset , 3B PKO A small population of expressing cells was observed, suggesting leaky expression from the maternal allele.
TS13: chorionic plate Present Single cells 3B PKO A small population of expressing cells was observed, suggesting leaky expression from the maternal allele.
Specimen 3B - Null: embryonic day 8.5; Slc38a4em#Smtb/Slc38a4em#Smtb (more )
Structure Level Pattern Image Note
TS13: ectoplacental cone Absent 3B Null , 3B Null inset
TS13: chorionic plate Absent 3B Null
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory