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Gene Expression Data
Assay Details
Assay
Reference: J:196346 Burgold T, et al., The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival. Cell Rep. 2012 Nov 29;2(5):1244-58
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6403178
Gene symbol: Phox2b
Gene name: paired-like homeobox 2b
Antibody: Anti-Phox2b
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen S3C Jmjd3+/+: embryonic day 18.5 (more )
Note: Double labeled: green - Phox2b; magenta - Tacr1 (assay MGI:6403157).
Structure Level Pattern Image Note
TS26: facial nucleus Present S3C Jmjd3+/+ Phox2b
TS26: parafascicular nucleus Present S3C Jmjd3+/+ Phox2b
TS26: medulla oblongata Present Regionally restricted S3C Jmjd3+/+ Phox2b Expression was detected in the retrotrapezoid nucleus.
Specimen S3C Jmjd3-/-: embryonic day 18.5; Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg (more )
Note: Double labeled: green - Phox2b; magenta - Tacr1 (assay MGI:6403157).
Structure Level Pattern Image Note
TS26: facial nucleus Present S3C Jmjd3-/- Phox2b Expression was normal in the mutant.
TS26: parafascicular nucleus Present S3C Jmjd3-/- Phox2b Expression was normal in the mutant.
TS26: medulla oblongata Present Regionally restricted S3C Jmjd3-/- Phox2b Expression was detected in the retrotrapezoid nucleus, as in wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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