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Gene Expression Data
Assay Details
Assay
Reference: J:169673 Weston MD, et al., MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival. Dev Dyn. 2011 Apr;240(4):808-19
Assay type: RNA in situ
MGI Accession ID: MGI:6402642
Gene symbol: Mir183
Gene name: microRNA 183
Probe: miR-183 probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: vestibulo-cochlear ganglion Strong 1A upper left statoacoustic ganglia
Specimen 1B apex: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cochlear ganglion Present 1B left Highest expression.
TS24: organ of Corti Present Regionally restricted 1B left Expressed as a distinct strip.
Specimen 1B base: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cochlear ganglion Present 1B right Highest expression.
TS24: organ of Corti Present Regionally restricted 1B right Expressed as a distinct strip.
Specimen 1C apex: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cochlear duct epithelium Present Regionally restricted 1C left Expressed in inner hair cells.
TS24: greater epithelial ridge Present Diffuse 1C left
TS24: cochlear ganglion Present 1C left
Specimen 1C base: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cochlear duct epithelium Present Regionally restricted 1C right Expressed in inner hair cells.
TS24: greater epithelial ridge Present Diffuse 1C right
Specimen 1C base inset: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cochlear duct epithelium Present Regionally restricted 1C inset Expressed in inner hair cells.
Specimen 2A: postnatal day 0 (more )
Note: base
Structure Level Pattern Image Note
TS27: cochlea epithelium Strong Regionally restricted 2A Expressed in inner and outer hair cells, gradually diminishing from base to apex. Outer hair cells appeared greater than inner hair cells.
TS27: cochlear ganglion Present 2A
Specimen 2A': postnatal day 0 (more )
Note: base
Structure Level Pattern Image Note
TS27: cochlea epithelium Strong Regionally restricted 2A' Expressed in inner and outer hair cells.
Specimen 2B: postnatal day 0 (more )
Note: apex
Structure Level Pattern Image Note
TS27: cochlea epithelium Present Regionally restricted 2B Expressed in inner and outer hair cells, gradually diminishing from base to apex. Outer hair cells appeared greater than inner hair cells.
TS27: cochlear ganglion Present 2B
Specimen 2B': postnatal day 0 (more )
Note: apex
Structure Level Pattern Image Note
TS27: cochlea epithelium Present Regionally restricted 2B' Expressed in inner and outer hair cells.
Specimen 2C: postnatal day 37 (more )
Note: base
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 2C Expressed in inner and outer hair cells, gradually diminishing toward the base. Inner hair cells appeared greater than outer hair cells.
TS28: cochlear ganglion Present 2C
Specimen 2C': postnatal day 37 (more )
Note: base
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 2C' Expressed in inner and outer hair cells.
Specimen 2D: postnatal day 37 (more )
Note: apex
Structure Level Pattern Image Note
TS28: cochlea epithelium Strong Regionally restricted 2D Expressed in inner and outer hair cells, gradually diminishing toward the base. Outer hair cells appeared similar to inner hair cells.
TS28: cochlear ganglion Present 2D
Specimen 2D': postnatal day 37 (more )
Note: apex
Structure Level Pattern Image Note
TS28: cochlea epithelium Strong Regionally restricted 2D' Expressed in inner and outer hair cells. Outer hair cells appeared greater than inner hair cells.
Specimen 3A cochlea control: embryonic day 18.5 (more )
Note: base
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Present 3A upper left Expressed in hair cells.
TS26: cochlear ganglion Present 3A upper left
Specimen 3A cochlea Neurog1 null: embryonic day 18.5; Neurog1tm1And/Neurog1tm1And (more )
Note: base
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Present 3A upper right Expressed in hair cells. Sensory neurons were altogether absent.
Specimen 3A vestibule control: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lateral semicircular canal epithelium Present 3A lower left
TS26: superior semicircular canal epithelium Present 3A lower left
TS26: utricle epithelium Present 3A lower left
Specimen 3A vestibule Neurog1 null: embryonic day 18.5; Neurog1tm1And/Neurog1tm1And (more )
Structure Level Pattern Image Note
TS26: lateral semicircular canal epithelium Present 3A lower right Similar as in the control.
TS26: saccule epithelium Present 3A lower right Similar as in the control.
TS26: superior semicircular canal epithelium Present 3A lower right Similar as in the control.
TS26: utricle epithelium Present 3A lower right Similar as in the control.
Specimen 3B cochlea control: embryonic day 18.5 (more )
Note: apex
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Present Regionally restricted 3B upper left Expressed in hair cells.
TS26: cochlear ganglion Present 3B upper left
Specimen 3B cochlea Atoh1 null: embryonic day 18.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Note: apex
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Absent 3B upper right
TS26: cochlear ganglion Weak 3B upper right
Specimen 3B vestibule control: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lateral semicircular canal epithelium Present 3B lower left
TS26: superior semicircular canal epithelium Present 3B lower left
TS26: utricle epithelium Present 3B lower left
Specimen 3B vestibule Atoh1 null: embryonic day 18.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS26: lateral semicircular canal epithelium Absent 3B lower right
TS26: superior semicircular canal epithelium Absent 3B lower right
TS26: utricle epithelium Absent 3B lower right
Specimen 3C cochlea control: postnatal day 2 (more )
Note: base
Structure Level Pattern Image Note
TS27: cochlea epithelium Present Regionally restricted 3C upper left Expressed in hair cells.
TS27: cochlear ganglion Present 3C upper left
Specimen 3C cochlea Pou4f3 mutant: postnatal day 2; Pou4f3ddl/Pou4f3ddl (more )
Note: base
Structure Level Pattern Image Note
TS27: cochlea epithelium Weak Regionally restricted 3C upper right Expressed in hair cells.
TS27: cochlear ganglion Weak 3C upper right
Specimen 3C vestibule control: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: utricle epithelium Present 3C lower left
TS27: vestibular epithelium Present 3C lower left
Specimen 3C vestibule Pou4f3 mutant: postnatal day 2; Pou4f3ddl/Pou4f3ddl (more )
Structure Level Pattern Image Note
TS27: utricle epithelium Absent 3C lower right
TS27: vestibular epithelium Absent 3C lower right
Specimen 4A control: postnatal day 18; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. apex
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4A left Expressed in hair cells.
TS28: cochlear ganglion Present 4A left
Specimen 4A control inset: postnatal day 18; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. apex
Structure Level Pattern Image Note
TS28: vestibular epithelium Present 4A left inset
Specimen 4A CKO: postnatal day 18; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. apex
Structure Level Pattern Image Note
TS28: cochlea epithelium Weak Regionally restricted 4A right Largely depleted expression in hair cells.
TS28: cochlear ganglion Present 4A right Same as in the control.
Specimen 4A CKO inset: postnatal day 18; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. apex
Structure Level Pattern Image Note
TS28: vestibular epithelium Weak 4A right inset Largely depleted expression.
Specimen S1: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cochlea epithelium Present Regionally restricted S1_left Expressed in inner and outer hair cells.
TS27: cochlear ganglion Present S1_left
Specimen S2 cochlea apical turn: postnatal day 100 (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Strong Regionally restricted S2_upper apical turn Expressed in inner and outer hair cells, gradually diminishing toward the base.
TS28: cochlear ganglion Present S2_upper apical turn
Specimen S2 cochlea middle turn: postnatal day 100 (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted S2_upper middle turn Expressed in inner and outer hair cells, gradually diminishing toward the base. Inner hair cells appeared greater than outer hair cells.
TS28: cochlear ganglion Present S2_upper middle turn
Specimen S2 cochlea basal turn: postnatal day 100 (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted S2_upper basal turn Expressed in inner and outer hair cells, gradually diminishing toward the base. Inner hair cells appeared greater than outer hair cells.
TS28: cochlear ganglion Present S2_upper basal turn
Specimen S2 cochlea base: postnatal day 100 (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Weak Regionally restricted S2_upper base Expressed in inner and outer hair cells, gradually diminishing toward the base. Inner hair cells appeared greater than outer hair cells.
TS28: cochlear ganglion Present S2_upper base
Specimen S2 lower left: postnatal day 100 (more )
Structure Level Pattern Image Note
TS28: anterior semicircular duct Present S2_lower left
TS28: lateral semicircular canal Present S2_lower left
TS28: utricle epithelium Present S2_lower left
TS28: vestibular epithelium Present S2_lower left
Specimen S2 lower middle: postnatal day 100 (more )
Structure Level Pattern Image Note
TS28: saccule epithelium Present S2_lower middle
Specimen S2 lower right: postnatal day 100 (more )
Structure Level Pattern Image Note
TS28: posterior semicircular canal Present S2_lower right
TS28: vestibular epithelium Present S2_lower right
Specimen S4 apex control: postnatal day 18; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cochlea epithelium Strong S4_upper left Expressed in inner and outer hair cells.
Specimen S4 apex CKO: postnatal day 18; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cochlea epithelium Weak S4_upper right Largely depleted expression in hair cells.
Specimen S4 base control: postnatal day 18; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted S4_lower left Expressed in inner and outer hair cells.
Specimen S4 base CKO: postnatal day 18; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cochlea epithelium Trace Regionally restricted S4_lower right Largely depleted expression in hair cells.
Specimen not shown: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Present Regionally restricted Expressed in inner and outer hair cells.
TS26: cochlear ganglion Present
Specimen not shown: postnatal week 2-3 (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Graded Formed longitudinal and radial gradients expression in hair cells. Basal hair cells show relatively less expression, especially in outer hair cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory