Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Krt6aem1(cre/ERT2)Tchn
Name:	keratin 6A; endonuclease-mediated mutation 1, Ting Chen
MGI ID:	MGI:6401425
Synonyms:	Krt6-CreER
Gene:	Krt6a  Location: Chr15:101598363-101602740 bp, - strand  Genetic Position: Chr15, 56.97 cM
Alliance:	Krt6aem1(cre/ERT2)Tchn page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Krt6aem1(cre/ERT2)Tchn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Krt6a (MGI:1100845)     CRISPR/Cas9 genome editing is used to insert an IRES-CreERT2-SV40poly cassette after exon 9. (J:285989)

Activity:	Tissue activity of this recombinase allele
Driver:	Krt6a (mouse) Summary of all recombinase alleles driven by Krt6a. Alliance mouse Krt6a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt6a Mutation:	25 strains or lines available

Original:	J:285989 Lu Z, et al., Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells. Elife. 2020 Jan 3;9:e52712
All:	1 reference(s)