About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:179737 Takano-Maruyama M, et al., Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis. Dev Dyn. 2012 Feb;241(2):229-41
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6388565
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: anti-Isl1
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2C: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: geniculate placode Present 2C
TS15: nodose placode Present 2C
TS15: petrosal placode Present 2C
Specimen 2D: embryonic day 9.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Structure Level Pattern Image Note
TS15: geniculate placode Present 2D Expression in this mutant is the same as in wild-type.
TS15: nodose placode Present 2D Expression in this mutant is the same as in wild-type.
TS15: petrosal placode Present 2D Expression in this mutant is the same as in wild-type.
Specimen 2E: embryonic day 10.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: nodose placode Present 2E
TS17: petrosal placode Present 2E
Specimen 2F: embryonic day 10.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: nodose placode Present 2F Expression in this mutant is the same as in wild-type.
TS17: petrosal placode Present 2F Expression in this mutant is the same as in wild-type.
Specimen 2G: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: inferior glossopharyngeal ganglion Present 2G
TS20: inferior vagus ganglion Present 2G
Specimen 2H: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: cranial ganglion Present Regionally restricted 2H The petrosal and nodose ganglia are missing in this mutant.
Specimen 3A: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3A
TS20: trigeminal ganglion Present 3A
Specimen 3B: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3B
TS20: cranial ganglion Present Regionally restricted 3B This mutant is missing the trigeminal ganglion. Expression is in a group of neurons that may contribute to the trigeminal ganglion.
Specimen 3C: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3C
TS20: trigeminal ganglion Present 3C
Specimen 3D: embryonic day 12.5; Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: trigeminal ganglion Present 3D
TS20: cranial ganglion Present Regionally restricted 3D The geniculate ganglion is missing in this mutant.
Specimen 3E: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3E
TS20: vestibulo-cochlear ganglion Present 3E
Specimen 3F: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: cranial ganglion Present Regionally restricted 3F This mutant has a complete loss of post-ganglionic neurons of the otic ganglion, as well as the placode-derived neurons of the trigeminal ganglion.
Specimen 4E: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS19: cranial ganglion Present 4E
Specimen 5A: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: petrosal placode Present 5A
Specimen 5B: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: cranial ganglion Present 5B
Specimen 6A: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: red - Isl1; blue Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS17: petrosal placode Present 6A
Specimen 6B: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: red - Isl1; blue Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS17: petrosal placode Present Single cells 6B
Specimen 6C: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS19: migrating neural crest Present 6C
Specimen 6D: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS19: migrating neural crest Present 6D
Specimen 6E: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: migrating neural crest Present 6E
Specimen 6F: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: migrating neural crest Absent 6F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory