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Gene Expression Data
Assay Details
Assay
Reference: J:136711 Zhao H, et al., Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008 Jun 15;318(2):276-88
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6386989
Gene symbol: Cdkn1b
Gene name: cyclin dependent kinase inhibitor 1B
Antibody: anti-p27
Results
Specimen 4M: embryonic day 12.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor, Fgfr3tm1Dor/Fgfr3tm1Dor, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lens Trace 4M Expression greatly reduced or absent in mutant lenses.
Specimen 4N: embryonic day 12.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor (more )
Structure Level Pattern Image Note
TS21: lens fiber Strong 4N Strong expression in fiber cells.
TS21: lens epithelium Weak 4N Minimal expression in epithelial cells.
Specimen 4O: embryonic day 16.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor, Fgfr3tm1Dor/Fgfr3tm1Dor, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lens Trace 4O Expression greatly reduced or absent in mutant lenses.
Specimen 4P: embryonic day 16.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor (more )
Structure Level Pattern Image Note
TS24: lens fiber Strong 4P Strong expression in fiber cells.
TS24: lens epithelium Weak 4P Minimal expression in epithelial cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory