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Gene Expression Data
Assay Details
Assay
Reference: J:136711 Zhao H, et al., Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008 Jun 15;318(2):276-88
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6386988
Gene symbol: Cdkn1c
Gene name: cyclin dependent kinase inhibitor 1C
Antibody: p57 antibody
Results
Specimen 4I: embryonic day 12.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor, Fgfr3tm1Dor/Fgfr3tm1Dor, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lens Trace 4I Expression greatly reduced or absent in mutant lenses.
Specimen 4J: embryonic day 12.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor (more )
Structure Level Pattern Image Note
TS21: lens Strong 4J Increased expression as cells begin process of differentiation into primary fiber cells.
Specimen 4K: embryonic day 16.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor, Fgfr3tm1Dor/Fgfr3tm1Dor, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lens Trace 4K Expression greatly reduced or absent in mutant lenses.
Specimen 4L: embryonic day 16.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm1Dor/Fgfr2tm1Dor (more )
Structure Level Pattern Image Note
TS24: lens Present 4L Increased expression as cells begin process of differentiation into secondary fiber cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory