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Gene Expression Data
Assay Details
Assay
Reference: J:272619 Aydogdu N, et al., TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. Development. 2018 Nov 26;145(23):dev171827
Assay type: RNA in situ
MGI Accession ID: MGI:6385537
Gene symbol: Tagln
Gene name: transgelin
Probe: Tagln probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2C control: embryonic day 18.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Present 2C control Tagln
Specimen 2C Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl: embryonic day 18.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Weak Patchy 2C Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl Tagln Expression was reduced to small patches in the conditional mutant.
Specimen 4B control E14.5: embryonic day 14.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS22: ureteral mesenchyme Absent 4B control E14.5 Tagln
Specimen 4B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl E14.5: embryonic day 14.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: ureteral mesenchyme Absent 4B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl E14.5 Tagln
Specimen 4B control E15.5: embryonic day 15.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS23: ureteral mesenchyme Present 4B control E15.5 Tagln
Specimen 4B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl E15.5: embryonic day 15.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: ureteral mesenchyme Absent 4B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl E15.5 Tagln
Specimen 4B control E16.5: embryonic day 16.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS24: ureteral mesenchyme Present 4B control E16.5 Tagln
Specimen 4B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl E16.5: embryonic day 16.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: ureteral mesenchyme Weak 4B Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl E16.5 Tagln
Specimen S4C control: embryonic day 18.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Present S4C control Tagln
Specimen S4C Tbx18cre/+;Tbx2fl/fl: embryonic day 18.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx18tm4(cre)Akis/Tbx18+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Present S4C Tbx18cre/+;Tbx2fl/fl Tagln Expression was normal.
Specimen S4C Tbx18cre/+;Tbx3fl/fl: embryonic day 18.5; Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Present S4C Tbx18cre/+;Tbx3fl/fl Tagln Expression was normal.
Specimen S4C Tbx18cre/+;Tbx2fl/+;Tbx3fl/+: embryonic day 18.5; Tbx2tm2.2Vmc/Tbx2+, Tbx3tm3.2Moon/Tbx3+, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Present S4C Tbx18cre/+;Tbx2fl/+;Tbx3fl/+ Tagln Expression was normal.
Specimen S4C Tbx18cre/+;Tbx2fl/fl;Tbx3fl/+: embryonic day 18.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3+, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Present S4C Tbx18cre/+;Tbx2fl/fl;Tbx3fl/+ Tagln Expression was normal.
Specimen S4C Tbx18cre/+;Tbx2fl/+;Tbx3fl/fl: embryonic day 18.5; Tbx2tm2.2Vmc/Tbx2+, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: ureteral smooth muscle layer Present S4C Tbx18cre/+;Tbx2fl/+;Tbx3fl/fl Tagln Expression was normal.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory