Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:280829
Chen Y, et al., The depletion of MARVELD1 leads to murine placenta accreta via integrin beta4-dependent trophoblast cell invasion. J Cell Physiol. 2018 Mar;233(3):2257-2269
|
|
Assay type:
|
Immunohistochemistry
|
|
MGI Accession ID:
|
MGI:6382098
|
|
Gene symbol:
|
Itgb4
|
|
Gene name:
|
integrin beta 4
|
|
|
Results
|
Specimen
6c +/+:
embryonic day 18.5
(more  )
Note: Double labeled: green - Itgb4; red - Krt18 (assay MGI:6382096).
Specimen
6c +/+:
(close  )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
|
Note:
|
Double labeled: green - Itgb4; red - Krt18 (assay MGI:6382096).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: labyrinthine zone |
Present |
|
6c +/+ Integrin b4
,
6c +/+ Merge
|
Expression is in the labyrinth layer trophoblast cells.
|
| TS26: trophectoderm |
Present |
|
6c +/+ Integrin b4
,
6c +/+ Merge
|
Expression is in the labyrinth layer trophoblast cells.
|
| TS28: placenta |
Present |
|
6c +/+ Integrin b4
,
6c +/+ Merge
|
Expression is in the labyrinth layer trophoblast cells.
|
Specimen
6c -/-:
(close )
|
Genetic Background:
|
involves: C57BL/6
|
|
Mutant Allele(s):
|
Marveld1tm1.2Liy/Marveld1tm1.2Liy
Tg(Nes-cre)1Kln/0
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
|
Note:
|
Conditional mutant. Double labeled: green - Itgb4; red - Krt18 (assay MGI:6382096).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: labyrinthine zone |
Present |
|
6c -/- Integrin b4
,
6c -/- Merge
|
Expression in the labyrinth layer trophoblast cells is reduced in this mutant.
|
| TS26: trophectoderm |
Present |
|
6c -/- Integrin b4
,
6c -/- Merge
|
Expression in the labyrinth layer trophoblast cells is reduced in this mutant.
|
| TS28: placenta |
Present |
|
6c -/- Integrin b4
,
6c -/- Merge
|
Expression in the labyrinth layer trophoblast cells is reduced in this mutant.
|
Specimen
6d +/+:
embryonic day 18.5
(more )
Note: Double labeled: green - Itgb4; red - Krt18 (assay MGI:6382096).
Specimen
6d +/+:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
|
Note:
|
Double labeled: green - Itgb4; red - Krt18 (assay MGI:6382096).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: trophectoderm |
Present |
Regionally restricted |
6d +/+ Integrin b4
,
6d +/+ Merge
|
Expression is in trophoblasts cells that invade the junctional region.
|
| TS28: placenta |
Present |
Regionally restricted |
6d +/+ Integrin b4
,
6d +/+ Merge
|
Expression is in trophoblasts cells that invade the junctional region.
|
Specimen
6d -/-:
(close )
|
Genetic Background:
|
involves: C57BL/6
|
|
Mutant Allele(s):
|
Marveld1tm1.2Liy/Marveld1tm1.2Liy
Tg(Nes-cre)1Kln/0
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
|
Note:
|
Conditional mutant. Double labeled: green - Itgb4; red - Krt18 (assay MGI:6382096).
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: trophectoderm |
Present |
|
6d -/- Integrin b4
,
6d -/- Merge
|
The number of rophoblasts cells that invade the junctional region has increased in this mutant.
|
| TS28: placenta |
Present |
|
6d -/- Integrin b4
,
6d -/- Merge
|
The number of rophoblasts cells that invade the junctional region has increased in this mutant.
|
|
Analysis Tools