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Gene Expression Data
Assay Details
Assay
Reference: J:68455 Howell CY, et al., Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. Cell. 2001 Mar 23;104(6):829-38
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6378223
Gene symbol: Dnmt1
Gene name: DNA methyltransferase 1
Antibody: anti-Dnmt antibody
Detection system: Secondary antibody coupled to fluorescein
Results
Specimen 1A: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: primary oocyte Strong 1A Expressed in the nuclei of growing oocytes, but excluded from nucleoli.
Specimen 1B: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: primary oocyte Present 1B Largely confined to the cytoplasm in a late-stage growing oocyte.
Specimen 1C: postnatal adult (more )
Structure Level Pattern Image Note
TS28: secondary oocyte Present 1C Organized in a shell within the oocyte cortex in ovulated meiosis II (MII) stage oocyte.
Specimen 1D: embryonic day 1.0 (more )
Note: 2-cell embryo
Structure Level Pattern Image Note
TS2: 2-cell stage embryo Present 1D Expressed in the cytoplasm.
Specimen 1E: embryonic day 2.0 (more )
Note: 4-cell embryo
Structure Level Pattern Image Note
TS3: 4-cell stage embryo Present 1E Expressed in the cytoplasm.
Specimen 1F: embryonic day 2.5 (more )
Note: 8-cell embryo
Structure Level Pattern Image Note
TS3: 8-cell stage embryo Present 1F Expressed in the nuclei, but excluded from nucleoli.
Specimen 1G: embryonic day 3.0 (more )
Note: 16-cell embryo
Structure Level Pattern Image Note
TS4: compacted morula Present 1G Expressed in the cytoplasm.
Specimen 1H: embryonic day 3.5 (more )
Note: blastocyst
Structure Level Pattern Image Note
TS4: blastocyst Present 1H Expressed in the cytoplasm.
Specimen 2D +/-: postnatal adult; Dnmt1tm1Jrc/Dnmt1+ (more )
Structure Level Pattern Image Note
TS28: oocyte of mature follicle Strong 2D upper
TS28: ovary follicle cell Present 2D upper
Specimen 2D -/-: postnatal adult; Dnmt1tm1Jrc/Dnmt1tm1Jrc (more )
Structure Level Pattern Image Note
TS28: oocyte of mature follicle Absent 2D lower
TS28: ovary follicle cell Present 2D lower
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory