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Gene Expression Data
Assay Details
Assay
Reference: J:117138 Kimura T, et al., The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression. Dev Biol. 2006 Dec 15;300(2):545-53
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6363496
Gene symbol: Ctnnb1
Gene name: catenin beta 1
Results
Specimen 2B beta-catenin (left): embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: primordial germ cell of gonad Present Regionally restricted 2B beta-catenin (left) Predominant expression in plasma membrane and cytoplasm, not in the nucleus.
Specimen 2B beta-catenin (right): embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: primordial germ cell of gonad Present Regionally restricted 2B beta-catenin (right) Predominant expression in plasma membrane and cytoplasm, not in the nucleus.
Specimen 3A beta-catenin (left): embryonic day 13.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: primordial germ cell of gonad Present Regionally restricted 3A beta-catenin (left) Strong expression in a significant proportion of primordial germ cells, in nuclei as well as in plasma membrane.
Specimen 3A beta-catenin (right): embryonic day 13.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: primordial germ cell of gonad Present Regionally restricted 3A beta-catenin (right) Strong expression in a significant proportion of primordial germ cells, in nuclei as well as in plasma membrane.
Specimen 3B beta-catenin Control: embryonic day 13.5 (more )
Note: Double labeled: red - beta-catenin (Ctnnb1); green - Pgc7 (Dppa3 assay MGI:6363485).
Structure Level Pattern Image Note
TS21: primordial germ cell of gonad Present Regionally restricted 3B beta-catenin Control Expression localized in plasma membrane and cytoplasm, not in the nucleus.
Specimen 3B beta-catenin Pten KO: embryonic day 13.5; Ptentm1Mak/Ptentm1Mak (more )
Note: Double labeled: red - beta-catenin (Ctnnb1); green - Pgc7 (Dppa3 assay MGI:6363485).
Structure Level Pattern Image Note
TS21: primordial germ cell of gonad Present Regionally restricted 3B beta-catenin Pten KO Expression localized in plasma membrane and cytoplasm, not in the nucleus.
Specimen 3C beta-catenin Control (left): postnatal week 2 (more )
Structure Level Pattern Image Note
TS28: germ cell of testis Present Regionally restricted 3C beta-catenin Control (left) Expression localized in plasma membrane and cytoplasm, not in the nucleus.
Specimen 3C beta-catenin Mutant (left): postnatal week 2; Ptentm1Mak/Ptentm1Mak (more )
Structure Level Pattern Image Note
TS28: germ cell of testis Present Regionally restricted 3C beta-catenin Mutant (left) Nuclear localization was not detected.
Specimen 3C beta-catenin Control (right): postnatal week 2 (more )
Structure Level Pattern Image Note
TS28: germ cell of ovary Present Regionally restricted 3C beta-catenin Control (right) Expression localized in plasma membrane and cytoplasm, not in the nucleus.
Specimen 3C beta-catenin Mutant (right): postnatal week 2; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: germ cell of ovary Present Regionally restricted 3C beta-catenin Mutant (right) Nuclear localization was not detected.
Specimen 4A E11.5 Mutant beta-catenin: embryonic day 11.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: primordial germ cell of gonad Present Regionally restricted 4A E11.5 Mutant (right) Nuclear expression in 15-30% of primordial germ cells in both male and female embryos at E11.5.
Specimen 4A E13.5 Mutant beta-catenin: embryonic day 13.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: germ cell of testis Present Regionally restricted 4A E13.5 Mutant (right) Nuclear localization of expression in approximately 20-30% of cells.
Specimen 4A E16.5 Mutant beta-catenin: embryonic day 16.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: germ cell of testis Present Regionally restricted 4A E16.5 Mutant (right) Authors report a drastic reduction in nuclear-localized expression.
Specimen 4B E11.5 Mutant beta-catenin: embryonic day 11.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: primordial germ cell of gonad Present Regionally restricted 4B E11.5 Mutant (right) Nuclear expression in 15-30% of primordial germ cells in both male and female embryos at E11.5.
Specimen 4B E13.5 Mutant beta-catenin: embryonic day 13.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: germ cell of ovary Present Regionally restricted 4B E13.5 Mutant (right) Nuclear localization of expression in approximately 20-30% of cells.
Specimen 4B E16.5 Mutant beta-catenin: embryonic day 16.5; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: germ cell of ovary Present Regionally restricted 4B E16.5 Mutant (right) Authors report a drastic reduction in nuclear-localized expression.
Specimen 5A Control beta-catenin: embryonic day 12.0 (more )
Note: Double labeled: green - beta-catenin (Ctnnb1); red - Lysotracker.
Structure Level Pattern Image Note
TS20: primordial germ cell of gonad Present 5A Control (lower)
Specimen 5A Mutant beta-catenin: embryonic day 12.0; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant. Double labeled: green - beta-catenin (Ctnnb1); red - Lysotracker.
Structure Level Pattern Image Note
TS20: primordial germ cell of gonad Present Regionally restricted 5A Mutant (lower) Authors report nuclear-localized expression in primordial germ cells at E12.0.
Specimen 5C Mutant beta-catenin: embryonic day 12.0; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant. Double labeled: green - beta-catenin (Ctnnb1); red - pHH3 (phospho-histone H3).
Structure Level Pattern Image Note
TS20: primordial germ cell of gonad Present Regionally restricted 5C Mutant pHH3 beta-catenin , 5C Mutant beta-catenin Authors report nuclear-localized expression in primordial germ cells at E12.0.
Specimen 5D Mutant beta-catenin: embryonic day 12.0; Alpltm1(cre)Nagy/Alpl+, Ctnnb1tm1Mmt/Ctnnb1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: primordial germ cell of gonad Present Regionally restricted 5D Mutant beta-catenin Authors report nuclear-localized expression in primordial germ cells at E12.0.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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