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Gene Expression Data
Assay Details
Assay
Reference: J:243865 Thierion E, et al., Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements. PLoS Genet. 2017 Jul;13(7):e1006903
Assay type: RNA in situ
MGI Accession ID: MGI:6362753
Gene symbol: Egr2
Gene name: early growth response 2
Probe: Krox20 cDNA5
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1B 4s +/deltaC: embryonic day 8.0; Rr111tm2.1Ics/Rr111+ (more )
Note: 4 somites
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 1B 4s upper Expressed in rhombomere 3.
Specimen 1B 4s deltaC/deltaC: embryonic day 8.0; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 4 somites
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 1B 4s lower Expressed in rhombomere 3, similar to the controls.
Specimen 1B 6s +/deltaC: embryonic day 8.0; Rr111tm2.1Ics/Rr111+ (more )
Note: 6 somites
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 1B 6s upper Expressed in rhombomere 3 and 5.
Specimen 1B 6s deltaC/deltaC: embryonic day 8.0; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 6 somites
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 1B 6s lower Expressed in rhombomere 3 and 5, similar to the controls.
Specimen 1B 8s +/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111+ (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 1B 8s upper
TS13: rhombomere 5 Present 1B 8s upper
Specimen 1B 8s deltaC/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 1B 8s lower Severely reduced expression compared to controls.
TS13: rhombomere 5 Present 1B 8s lower Similar to the controls.
Specimen 1B 10s +/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111+ (more )
Note: 10 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 1B 10s upper
TS13: rhombomere 5 Present 1B 10s upper
Specimen 1B 10s deltaC/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 10 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Weak 1B 10s lower Severely reduced expression compared to controls.
TS13: rhombomere 5 Present 1B 10s lower Slightly reduced compared to controls.
Specimen 1B 12s +/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111+ (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 1B 12s upper
TS13: rhombomere 5 Present 1B 12s upper
Specimen 1B 12s deltaC/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Absent 1B 12s lower
TS13: rhombomere 5 Present 1B 12s lower Slightly reduced compared to controls.
Specimen 1B 14s +/deltaC: embryonic day 9.0; Rr111tm2.1Ics/Rr111+ (more )
Note: 14 somites
Structure Level Pattern Image Note
TS14: rhombomere 3 Present 1B 14s upper
TS14: rhombomere 5 Present 1B 14s upper
Specimen 1B 14s deltaC/deltaC: embryonic day 9.0; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 14 somites
Structure Level Pattern Image Note
TS14: rhombomere 3 Absent 1B 14s lower
TS14: rhombomere 5 Present 1B 14s lower Slightly reduced compared to controls.
Specimen 2A 8s WT: embryonic day 8.5 (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2A WT upper
TS13: rhombomere 5 Present 2A WT upper
Specimen 2A 12s WT: embryonic day 8.5 (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2A WT lower
TS13: rhombomere 5 Present 2A WT lower
Specimen 2A 8s +/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2+ (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2A +/cre upper Similar to the wild-type controls.
TS13: rhombomere 5 Present 2A +/cre upper Similar to the wild-type controls.
Specimen 2A 12s +/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2+ (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2A +/cre lower Similar to the wild-type controls.
TS13: rhombomere 5 Present 2A +/cre lower Similar to the wild-type controls.
Specimen 2A 8s deltaA/deltaA: embryonic day 8.5; Rr102tm1.2Ics/Rr102tm1.2Ics (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2A deltaA/deltaA upper Severely reduced expression compared to controls.
TS13: rhombomere 5 Present 2A deltaA/deltaA upper Similar to the controls.
Specimen 2A 12s deltaA/deltaA: embryonic day 8.5; Rr102tm1.2Ics/Rr102tm1.2Ics (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Absent 2A deltaA/deltaA lower
TS13: rhombomere 5 Present 2A deltaA/deltaA lower Slightly reduced compared to controls.
Specimen 2A 8s deltaC/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Weak 2A deltaC/deltaC upper Severely reduced expression compared to controls.
TS13: rhombomere 5 Present 2A deltaC/deltaC upper Similar to the controls.
Specimen 2A 12s deltaC/deltaC: embryonic day 8.5; Rr111tm2.1Ics/Rr111tm2.1Ics (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Absent 2A deltaC/deltaC lower
TS13: rhombomere 5 Present 2A deltaC/deltaC lower Slightly reduced compared to controls.
Specimen 2A 8s deltaA/deltaC: embryonic day 8.5; Rr102tm1.2Ics/Rr102+, Rr111tm2.1Ics/Rr111+ (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Weak 2A deltaA/deltaC upper Severely reduced expression compared to controls.
TS13: rhombomere 5 Present 2A deltaA/deltaC upper Similar to the controls.
Specimen 2A 12s deltaA/deltaC: embryonic day 8.5; Rr102tm1.2Ics/Rr102+, Rr111tm2.1Ics/Rr111+ (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Absent 2A deltaA/deltaC lower
TS13: rhombomere 5 Present 2A deltaA/deltaC lower Slightly reduced compared to controls.
Specimen 2B 6s +/Cre: embryonic day 8.0; Egr2tm2(cre)Pch/Egr2+ (more )
Note: 6 somites
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 2B 6s upper Expressed in rhombomere 3 and 5.
Specimen 2B 6s Cflox/Cre: embryonic day 8.0; Egr2tm2(cre)Pch/Egr2tm2Ics (more )
Note: Conditional mutant. 6 somites
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 2B 6s lower Expressed in rhombomere 3 and 5 (r3, r5). Reduced expression in r3, and similar expression in r5, compared to the controls.
Specimen 2B 8s +/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2+ (more )
Note: 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2B 8s upper
TS13: rhombomere 5 Present 2B 8s upper
Specimen 2B 8s Cflox/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2tm2Ics (more )
Note: Conditional mutant. 8 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2B 8s lower Reduced expression compared to controls.
TS13: rhombomere 5 Present 2B 8s lower Similar to the controls.
Specimen 2B 10s +/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2+ (more )
Note: 10 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2B 10s upper
TS13: rhombomere 5 Present 2B 10s upper
Specimen 2B 10s Cflox/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2tm2Ics (more )
Note: Conditional mutant. 10 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2B 10s lower Reduced expression compared to controls.
TS13: rhombomere 5 Present 2B 10s lower Similar to the controls.
Specimen 2B 12s +/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2+ (more )
Note: 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Present 2B 12s upper
TS13: rhombomere 5 Present 2B 12s upper
Specimen 2B 12s Cflox/Cre: embryonic day 8.5; Egr2tm2(cre)Pch/Egr2tm2Ics (more )
Note: Conditional mutant. 12 somites
Structure Level Pattern Image Note
TS13: rhombomere 3 Absent 2B 12s lower
TS13: rhombomere 5 Present 2B 12s lower Similar to the controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory