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Gene Expression Data
Assay Details
Assay
Reference: J:270176 Tian Z, et al., Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochim Biophys Acta Mol Basis Dis. 2018 Aug;1864(8):2623-2632
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6361560
Gene symbol: Cdc42
Gene name: cell division cycle 42
Antibody: anti-Cdc42
Detection system: Secondary antibody
Assay notes: Fixative was 4% formaldehyde.
Results
Specimen 1A Incisor: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: incisor Present 1A Cdc42 Incisor Expression is in all cells of the tooth germ.
TS27: jaw bone Present 1A Cdc42 Incisor
TS27: oral epithelium Present 1A Cdc42 Incisor
TS27: oral mucosa Present 1A Cdc42 Incisor
TS27: jaw Present 1A Cdc42 Incisor Expression is in connective tissues.
Specimen 1A Molar: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: molar Present 1A Cdc42 Molar Expression is in all cells of the tooth germ.
TS27: jaw bone Present 1A Cdc42 Molar
TS27: oral epithelium Present 1A Cdc42 Molar
TS27: oral mucosa Present 1A Cdc42 Molar
TS27: jaw Present 1A Cdc42 Molar Expression is in connective tissues.
Specimen 1 C WT Secretory: postnatal month 2; Cdc42tm1Yizh/? (more )
Note: Control animals (WT) were either homozygous Cdc42tm1Yizh/Cdc42tm1Yizh or heterozygous Cdc42tm1Yizh/+.
Structure Level Pattern Image Note
TS28: lower jaw incisor enamel organ Present Regionally restricted 1C WT Secretory Expression is in ameloblasts.
Specimen 1 C KO Secretory: postnatal month 2; Cdc42tm1Yizh/Cdc42tm1Yizh, Tg(KRT5-cre)1Xya/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: incisor dental pulp Present Regionally restricted 1C KO Secretory Expression is in odontoblasts and other tissues.
TS28: lower jaw incisor Present Regionally restricted 1C KO Secretory Expression is in odontoblasts and other tissues.
TS28: lower jaw incisor enamel organ Absent 1C KO Secretory Expression is absent in ameloblasts.
Specimen 1 C WT Maturation: postnatal month 2; Cdc42tm1Yizh/? (more )
Note: Control animals (WT) were either homozygous Cdc42tm1Yizh/Cdc42tm1Yizh or heterozygous Cdc42tm1Yizh/+.
Structure Level Pattern Image Note
TS28: lower jaw incisor enamel organ Present Regionally restricted 1C WT Maturation Expression is in ameloblasts.
Specimen 1 C KO Maturation: postnatal month 2; Cdc42tm1Yizh/Cdc42tm1Yizh, Tg(KRT5-cre)1Xya/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: incisor dental pulp Present 1C KO Maturation Expression is in odontoblasts and other tissues.
TS28: lower jaw incisor Present 1C KO Maturation Expression is in odontoblasts and other tissues.
TS28: lower jaw incisor enamel organ Absent 1C KO Maturation Expression is absent in ameloblasts.
Specimen S1 E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tooth epithelium Present S1_E13.5 Merge , S1_E13.5 Expression is in the cells originating from and surrounding the ectoderm.
TS21: tooth bud Present S1_E13.5 Merge , S1_E13.5
Specimen S1 E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: enamel organ Present Regionally restricted S1_E15.5 , S1_E15.5 Merge Expression is in the ectoderm-derived cells.
TS23: inner enamel epithelium Present Regionally restricted S1_E15.5 , S1_E15.5 Merge Expression is in the ectoderm-derived cells.
TS23: outer enamel epithelium Present Regionally restricted S1_E15.5 , S1_E15.5 Merge Expression is in the ectoderm-derived cells.
TS23: dental sac Weak S1_E15.5 Merge , S1_E15.5
TS23: cap stage tooth Present Regionally restricted S1_E15.5 , S1_E15.5 Merge
Specimen S1 E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: outer enamel epithelium Weak S1_E17.5 Merge , S1_E17.5
TS25: early bell stage tooth Weak Regionally restricted S1_E17.5 , S1_E17.5 Merge
Specimen S1 P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: enamel organ Present S1_P0 Merge , S1_P0
TS27: bell stage tooth Present S1_P0 Merge , S1_P0
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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