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Gene Expression Data
Assay Details
Assay
Reference: J:226703 Shimada M, et al., Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015 Oct 1;34(19):2465-80
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6358709
Gene symbol: H2ax
Gene name: H2A.X variant histone
Results
Specimen 2B Control gH2AX: embryonic day 15.5 (more )
Note: Double labeled: red - H2ax; red - Pcna (assay MGI:6358710).
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Trace Regionally restricted 2B Control gH2AX , 2B Control Merge
Specimen 2B Xrcc1 Nes-Cre gH2AX: embryonic day 15.5; Xrcc1tm1Pmc/Xrcc1tm1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - H2ax; red - Pcna (assay MGI:6358710).
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Weak Regionally restricted 2B Xrcc1 Nes-Cre Merge , 2B Xrcc1 Nes-Cre gH2AX Small nuclear puncta indicating DNA damage.
Specimen 2B Lig4 Nes-Cre gH2AX: embryonic day 15.5; Lig4tm1Pmc/Lig4tm1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present Regionally restricted 2B Lig4 Nes-Cre Merge , 2B Lig4 Nes-Cre gH2AX Large diffuse apoptotic foci.
Specimen 2B Pnkp Nes-Cre gH2AX: embryonic day 15.5; Pnkptm1.1Pmc/Pnkptm1.1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - H2ax; red - Pcna (assay MGI:6358710).
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Strong Regionally restricted 2B Pnkp Nes-Cre gH2AX inset , 2B Pnkp Nes-Cre Merge , 2B Pnkp Nes-Cre gH2AX Small nuclear puncta indicating DNA damage and also large diffuse apoptotic foci.
Specimen 6C control gH2AX: embryonic day 13.5 (more )
Note: Double labeled: red - H2ax; red - Pcna (assay MGI:6358710).
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Trace Regionally restricted 6C control Merge , 6C control gH2AX
Specimen 6C Pnkp Neo/Neo gH2AX: embryonic day 13.5; Pnkptm1Pmc/Pnkptm1Pmc (more )
Note: Double labeled: red - H2ax; red - Pcna (assay MGI:6358710).
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Strong Regionally restricted 6C Pnkp Neo/Neo gH2AX , 6C Pnkp Neo/Neo Merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory