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Gene Expression Data
Assay Details
Assay
Reference: J:226703 Shimada M, et al., Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015 Oct 1;34(19):2465-80
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6358703
Gene symbol: Pou3f2
Gene name: POU domain, class 3, transcription factor 2
Antibody: Brn2 antibody (GTX114650)
Detection system: fluorescein
Results
Specimen 1E Control Brn2: postnatal day 2 (more )
Note: Triple labeled: green - Pou3f2; red - Satb2 (assay MGI:6358701); blue - DAPI.
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 1E Control Brn2 , 1E Control Merge (left) Expression in upper layer neurons.
Specimen 1E PNKP nes-cre Brn2: postnatal day 2; Pnkptm1.1Pmc/Pnkptm1.1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Triple labeled: green - Pou3f2; red - Satb2 (assay MGI:6358701); blue - DAPI.
Structure Level Pattern Image Note
TS27: neocortex Weak Regionally restricted 1E PNKP nes-cre Merge (left) , 1E PNKP nes-cre Brn2 Authors state the ordered six-layer lamination is maintained, but there were reduced numbers of neurons, particularly in upper cortical layers.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
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