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Gene Expression Data
Assay Details
Assay
Reference: J:170258 Mavromatakis YE, et al., Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6355452
Gene symbol: Th
Gene name: tyrosine hydroxylase
Results
Specimen 8A: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2+ (more )
Note: Control; genotype either Foxa fl/fl; Foxa1 +/+ or Foxa2 fl/fl; Foxa1 +/-
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8A Expression was detected in dopaminergic neurons in the ventral midbrain.
Specimen 8B: embryonic day 12.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8B The number of dopaminergic neurons was severely reduced in the ventral midbrain of the E12.5 conditional knockout.
Specimen 8C: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc (more )
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8C In these mutants, there was a 50% reduction in the number of dopaminergic neurons.
Specimen 8D: embryonic day 12.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 8D The number of dopaminergic neurons was reduced in the double conditional knockout mutant.
Specimen 8M: embryonic day 18.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2+ (more )
Note: Control; genotype either Foxa fl/fl; Foxa1 +/+ or Foxa2 fl/fl; Foxa1 +/-
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8M Expression was detected in dopaminergic neurons in the ventral midbrain.
Specimen 8N: embryonic day 18.5; Foxa2tm1Khk/Foxa2tm1Khk, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8N There was almost a complete recovery of dopaminergic neurons in the conditional knockout mutants by E18.5.
Specimen 8O: embryonic day 18.5; Foxa1tm1Gsc/Foxa1tm1Gsc (more )
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8O Expression of dopaminergic neurons appeared normal at E18.5 in this mutant.
Specimen 8P: embryonic day 18.5; Foxa1tm1Gsc/Foxa1tm1Gsc, Foxa2tm1Khk/Foxa2tm1Khk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 8P Expression of dopaminergic neurons does not recover to normal in the double conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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