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Gene Expression Data
Assay Details
Assay
Reference: J:181271 Westmoreland JJ, et al., Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6343209
Gene symbol: Cldn1
Gene name: claudin 1
Antibody: Claudin-1 antibody (51-9000)
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 2A: embryonic day 10.5 (more )
Note: Double labeled: red - Cldn1; green - Pdx1 (assay MGI:6343237).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 2A Expression of Cldn1 was detected in nearly every Pdx1-positive cell (lateral membrane).
Specimen 2B: embryonic day 10.5 (more )
Note: Double labeled: red - Cldn1; green - Tjp1 (assay MGI:6343238).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 2B Expression was extensively localized throughout the membrane of the unpolarized pancreatic epithelium, which was also nearly devoid of Tjp1.
Specimen 2C: embryonic day 12.5 (more )
Note: Double labeled: red - Cldn1; green - Tjp1 (assay MGI:6343238).
Structure Level Pattern Image Note
TS20: pancreas epithelium Present Regionally restricted 2C Co-expression with Tjp1 was toward the lumen of the pancreatic epithelium in discrete areas.
Specimen not shown: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: pancreas Absent
Specimen not shown: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: pancreas Absent
Specimen 2D: postnatal day 5 (more )
Note: Double labeled: red - Cldn1; green - Tjp1 (assay MGI:6343238).
Structure Level Pattern Image Note
TS28: pancreatic duct Present Regionally restricted 2D Extensive colocalization was observed with Tjp1 in tight junctions.
Specimen 2E: postnatal day 5 (more )
Note: Double labeled: red - Cldn1; green - Tjp1 (assay MGI:6343238).
Structure Level Pattern Image Note
TS28: pancreatic duct Present Regionally restricted 2E Extensive colocalization was observed with Tjp1 in tight junctions.
TS28: islets of Langerhans Absent 2E
Specimen 2F: postnatal day 5 (more )
Note: Double labeled: red - Cldn1; green - Tjp1 (assay MGI:6343238).
Structure Level Pattern Image Note
TS28: pancreatic acinus Present Regionally restricted 2F Extensive colocalization was observed with Tjp1 in tight junctions.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory