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Gene Expression Data
Assay Details
Assay
Reference: J:271100 Shen B, et al., Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1221-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6314704
Gene symbol: Tie1
Gene name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Results
Specimen 1D ICD/ICD Tie-1: embryonic day 10.5; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: red - Tie1; green - Pecam1 (assay MGI:6314705).
Structure Level Pattern Image Note
TS17: blood vessel endothelium Weak 1D ICD/ICD Tie-1 , 1D ICD/ICD Overlay Authors report weak expression of truncated Tie1 in blood vascular endothelial cells.
Specimen 1D +/ICD Tie-1: embryonic day 10.5; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: red - Tie1; green - Pecam1 (assay MGI:6314705).
Structure Level Pattern Image Note
TS17: blood vessel endothelium Present 1D +/ICD Overlay , 1D +/ICD Tie-1
Specimen 1D +/+ Tie-1: embryonic day 10.5 (more )
Note: Double labeled: red - Tie1; green - Pecam1 (assay MGI:6314705).
Structure Level Pattern Image Note
TS17: blood vessel endothelium Present 1D +/+ Tie-1 , 1D +/+ Overlay
Specimen 3A Tie-1: embryonic day 18.5 (more )
Note: Double labeled: red - Tie1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS26: back skin Present Regionally restricted 3A Overlay , 3A Tie-1
TS26: lymphatic system Strong Regionally restricted 3A Tie-1 , 3A Overlay Strong expression in lymphatic valve.
Specimen 3B Tie-1: postnatal week 5 (more )
Note: Double labeled: green - Tie1; red - Pecam1 (assay MGI:6314705).
Structure Level Pattern Image Note
TS28: ear skin Present Regionally restricted 3B Tie-1 , 3B Overlay
TS28: lymphatic system Strong Regionally restricted 3B Overlay , 3B Tie-1 Strong expression in lymphatic valve.
Specimen 3C ICD/ICD Tie-1: embryonic day 15.75; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Triple labeled: blue - Tie1; green - Prox1 (assay MGI:6314707); red - Lyve1 (assay MGI:6314706).
Structure Level Pattern Image Note
TS23: back skin Present Regionally restricted 3C ICD/ICD Overlay , 3C ICD/ICD Tie-1
TS23: lymphatic system Present Regionally restricted 3C ICD/ICD Overlay , 3C ICD/ICD Tie-1 Authors report remodeling of primary lymphatic network to form collecting vessels does not occur in homozygous mutant mice.
Specimen 3C +/ICD Tie-1: embryonic day 15.75; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Triple labeled: blue - Tie1; green - Prox1 (assay MGI:6314707); red - Lyve1 (assay MGI:6314706).
Structure Level Pattern Image Note
TS23: back skin Present Regionally restricted 3C +/ICD Tie-1 , 3C +/ICD Overlay
Specimen 4B ICD/ICD Tie-1: embryonic day 17.5; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: red - Tie1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS25: lymphatic system Present Regionally restricted 4B ICD/ICD Tie-1 , 4B ICD/ICD Overlay Authors report disruption of remodeling of primary lymphatic network in homozygous mutant mice.
Specimen 4B +/ICD Tie-1: embryonic day 17.5; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: red - Tie1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS25: gut mesentery Present Regionally restricted 4B +/ICD Overlay , 4B +/ICD Tie-1 Expression in lymphatic endothelial cells.
Specimen 4B +/+ Tie-1: embryonic day 17.5 (more )
Note: Double labeled: red - Tie1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS25: gut mesentery Present Regionally restricted 4B +/+ Overlay , 4B +/+ Tie-1 Expression in lymphatic endothelial cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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