Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	U2surpem1(IMPC)J
Name:	U2 snRNP-associated SURP domain containing; endonuclease-mediated mutation 1, Jackson
MGI ID:	MGI:6306472
Gene:	U2surp  Location: Chr9:95338951-95394049 bp, - strand  Genetic Position: Chr9, 50.11 cM, cytoband E4
Alliance:	U2surpem1(IMPC)J page
IMPC:	U2surp gene page

Strain of Origin:	C57BL/6NJ
Project Collection:	IMPC

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TCTGTTATCACATTATCCAA and GTTACACAAGAACTGCTGTT, which resulted in a 189 bp deletion beginning at Chromosome 9 position 95,493,667 bp and ending after 95,493,855 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000219474 (exon 5) and 74 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 107 and early truncation 38 amino acids later. (J:188991) Inheritance:    Not Specified

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any U2surp Mutation:	72 strains or lines available

Original:	J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:	2 reference(s)