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Gene Expression Data
Assay Details
Assay
Reference: J:196291 Ryu YK, et al., An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation. Dev Biol. 2013 May 1;377(1):79-89
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6294269
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: anti-TH
Detection system: horseradish peroxidase
Results
Specimen 2D WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: sympathetic ganglion Present 2D WT
Specimen 2D Wnt1::Cre;Wnt5a fl/-: embryonic day 16.5; Wnt5atm1Amc/Wnt5atm1.1Krvl, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: sympathetic ganglion Present 2D Wnt::Cre;Wnt5a fl/- Authors state the general architecture of the sympathetic chain in mutant is normal, with ganglia size comparable to that of wildtype.
Specimen 3A WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: salivary gland Present 3A WT
Specimen 3A Wnt1::Cre;Wnt5a fl/-: embryonic day 16.5; Wnt5atm1Amc/Wnt5atm1.1Krvl, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: salivary gland Weak Regionally restricted 3A Wnt::Cre;Wnt5a fl/- Authors report reduced sympathetic arborization.
Specimen 3C WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: thymus Present 3C WT
Specimen 3C Wnt1::Cre;Wnt5a fl/-: embryonic day 16.5; Wnt5atm1Amc/Wnt5atm1.1Krvl, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: thymus Weak Regionally restricted 3C Wnt::Cre;Wnt5a fl/- Authors report reduced sympathetic arborization.
Specimen 3E WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: heart Present 3E WT
Specimen 3E Wnt1::Cre;Wnt5a fl/-: embryonic day 16.5; Wnt5atm1Amc/Wnt5atm1.1Krvl, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: heart Weak Regionally restricted 3E Wnt::Cre;Wnt5a fl/- Authors report reduced sympathetic arborization.
Specimen 3G WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: spleen Present 3G WT
Specimen 3G Wnt1::Cre;Wnt5a fl/-: embryonic day 16.5; Wnt5atm1Amc/Wnt5atm1.1Krvl, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: spleen Weak Regionally restricted 3G Wnt::Cre;Wnt5a fl/- Authors report reduced sympathetic arborization.
Specimen 3I WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: bladder Present 3I WT
Specimen 3I Wnt1::Cre;Wnt5a fl/-: embryonic day 16.5; Wnt5atm1Amc/Wnt5atm1.1Krvl, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: bladder Weak Regionally restricted 3I Wnt::Cre;Wnt5a fl/- Authors report reduced sympathetic arborization.
Specimen 4D Wnt5a fl/fl: embryonic day 16.5; Wnt5atm1.1Krvl/Wnt5atm1.1Krvl (more )
Structure Level Pattern Image Note
TS24: salivary gland Present 4D Wnt5a fl/fl
Specimen 4D TH::Cre;Wnt5a fl/fl: embryonic day 16.5; Wnt5atm1.1Krvl/Wnt5atm1.1Krvl, Tg(Th-cre)#Gsat/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: salivary gland Weak Regionally restricted 4D TH::Cre;Wnt5a fl/fl Authors report reduced sympathetic innervation of salivary gland.
Specimen 4F Wnt5a fl/fl: embryonic day 16.5; Wnt5atm1.1Krvl/Wnt5atm1.1Krvl (more )
Structure Level Pattern Image Note
TS24: heart Present 4F Wnt5a fl/fl
Specimen 4F TH::Cre;Wnt5a fl/fl: embryonic day 16.5; Wnt5atm1.1Krvl/Wnt5atm1.1Krvl, Tg(Th-cre)#Gsat/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: heart Weak Regionally restricted 4F TH::Cre;Wnt5a fl/fl Authors report reduced sympathetic innervation of heart.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory