Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(tetO-ACMSD)Mmf
Name:	collagen, type I, alpha 1; targeted mutation 1, Mirella L Meyer-Ficca
MGI ID:	MGI:6294155
Synonyms:	Col1A1tm6(tetO-hACMSD)MMF
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(tetO-ACMSD)Mmf page

Germline Transmission:	Earliest citation of germline transmission: J:271258
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Humanized sequence, Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(tetO-ACMSD)Mmf expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human ACMSD (130013) Acmsd  (MGI:2386323)   Col1a1tm1(tetO-ACMSD)Mmf expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note Not Specified tetO   Mutation details: RMCE on KH2 ES cells introduced into the 3' UTR a tetracycline-inducible CMV minimal promoter driving inducible expression of the human aminocarboxymuconate semialdehyde decarboxylase cDNA. The ES cells also contain the Gt(ROSA)26Sortm1(rtTA*M2)Jae allele. By treating this mouse line with doxycycline, rtTA*M2 binds the tetO promoter and human aminocarboxymuconate semialdehyde decarboxylase is expressed. (J:271258)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:271258 Palzer L, et al., Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD(+) Synthesis. Cell Rep. 2018 Oct 30;25(5):1359-1370.e4
All:	2 reference(s)