About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:32851 Andermarcher E, et al., Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis. Dev Genet. 1996;18(3):254-66
Assay type: RNA in situ
MGI Accession ID: MGI:6281711
Gene symbol: Hgf
Gene name: hepatocyte growth factor
Probe: HGF/SF cDNA2 (clone P48)
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen pre-streak stage not shown: embryonic day 6.25 (more )
Structure Level Pattern Image Note
TS8: embryo Absent No expression before onset of gastrulation.
Specimen 1A: embryonic day 6.5-6.75 (more )
Note: early-mid-streak stage
Structure Level Pattern Image Note
TS9: primitive streak Strong 1A At onset of gastrulation, strong expression in region of the developing primitive streak.
Specimen 1D: embryonic day 6.75-7.0 (more )
Note: mid-late streak stage
Structure Level Pattern Image Note
TS10: primitive streak Present Regionally restricted 1D Expression follows the spatial progression of the streak and becomes more localized in intermediate and rostral part of the streak.
TS10: node Present 1D Starting at the late primitive streak, expression in region corresponding to the node.
Specimen mid-late streak stage not shown: embryonic day 6.75-7.0 (more )
Structure Level Pattern Image Note
TS10: embryo mesoderm Present Regionally restricted Expression in the area of mesoderm from which the primordium of the heart will differentiate.
TS10: definitive endoderm Present Regionally restricted Expression in foregut endoderm.
Specimen neural plate / headfold stage not shown: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: allantois Absent
Specimen 1G: embryonic day 7.75 (more )
Note: late headfold stage
Structure Level Pattern Image Note
TS11: node Present 1G
TS11: neural groove Present Regionally restricted 1G Expression localized in intermediate and rostral part of neural groove, corresponding to area where notochord is forming.
TS11: notochordal plate Present 1G
TS11: definitive endoderm Present Regionally restricted 1G Expression in the prospective foregut.
TS11: future brain Absent 1G No expression in prospective forebrain.
Specimen 3-5 somite stage not shown: embryonic day 8.0 (more )
Structure Level Pattern Image Note
TS12: allantois Present Expression becomes detectable in allantois.
TS12: common atrial chamber Strong Regionally restricted High levels of expression in common atrium and ventricle. Expression overlaps with c-met in both myocardial and endocardial tissues.
TS12: primitive ventricle Strong Regionally restricted High levels of expression in common atrium and ventricle. Expression overlaps with c-met in both myocardial and endocardial tissues.
TS12: somite Present Uniform Expression evenly distributed over newly formed somites, overlapping with that of c-met.
Specimen 1J: embryonic day 10.0 (more )
Note: 30-35 somite stage
Structure Level Pattern Image Note
TS16: 1st branchial arch Present 1J
TS16: 2nd branchial arch Present 1J
TS16: 3rd branchial arch Present 1J
TS16: heart Present
TS16: limb bud Present
Specimen 2A: embryonic day 6.75-7.0 (more )
Structure Level Pattern Image Note
TS10: primitive streak Present Regionally restricted 2A Expression along the primitive streak, confined to mesodermal cells of the streak
TS10: primitive endoderm Present Expression in the visceral endoderm.
TS10: embryo ectoderm Absent No expression in ectodermal layer.
TS10: embryo mesoderm Present Regionally restricted Expression in the notochordal plate.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory