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Gene Expression Data
Assay Details
Assay
Reference: J:29484 Bennett JH, et al., Bone morphogenetic protein-2 and -4 expression during murine orofacial development. Arch Oral Biol. 1995 Sep;40(9):847-54
Assay type: RNA in situ
MGI Accession ID: MGI:6277149
Gene symbol: Bmp2
Gene name: bone morphogenetic protein 2
Probe: BMP2 cDNA
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen E9.5 not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: heart Present Non-Uniform Non-uniform distribution of expression principally round the heart primordia.
TS15: 1st branchial arch mandibular component Weak Little expression in forelimb bud, and maxillary and mandibular processes.
TS15: 1st branchial arch maxillary component Weak Little expression in forelimb bud, and maxillary and mandibular processes.
TS15: forelimb bud Weak Little expression in forelimb bud, and maxillary and mandibular processes.

Specimen E10.5 not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: dorsal aorta Strong Considerable expression in paired aortae.
TS17: limb bud Present Regionally restricted Expression in apices of limb buds.
TS17: 1st branchial arch mandibular component mesenchyme Present Marginal increase in expression in mesenchyme of mandibular process.
TS17: head mesenchyme Present Regionally restricted Increased expression in mesenchyme adjacent to junction between midbrain and hindbrain.

Specimen E11.5 not shown: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: embryo Present Authors state changes seen at E10.5 are still present at E11.5.

Specimen 1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tooth epithelium Present Regionally restricted 1A Expression in epithelium of ventral surface of tongue.
TS21: oral region Present Regionally restricted 1A Expression in floor of mouth.

Specimen 1B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tongue epithelium Present Regionally restricted 1B No expression in epithelium of dorsum of tongue.
TS21: primary palate Absent 1B

Specimen 1C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: oral region mesenchyme Present Diffuse 1C Diffuse expression throughout mesenchymal tissues of floor of oral cavity.
TS21: tongue mesenchyme Weak 1C
TS21: Meckel's cartilage Strong Regionally restricted 1C Strong bilateral foci of expression in region of Meckel's cartilages.
TS21: mesenchyme derived from neural crest Present Regionally restricted 1C Expression in ectomesenchyme of cranial base.
TS21: chondrocranium pre-cartilage condensation Absent 1C No expression in parachordal cartilage.
TS21: central nervous system Absent 1C No expression in neural tube.
TS21: palatal shelf Absent 1C No expression in mesenchyme of palatal processes, which have not yet fused.

Specimen 1D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tongue epithelium Present Regionally restricted 1D Authors report a sharp cut-off between strong expression in the epithelium of the ventral surface of tongue and no expression in the dorsum.

Specimen 2A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw tooth dental lamina Present 2A Expression in thickened dental lamina a earliest morphologically recognizable stage of mandibular tooth development.
TS21: tooth epithelium Present Regionally restricted 2A Expression in enamel epithelium.

Specimen 2B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw tooth dental lamina Weak 2B Lesser extent of expression in dental lamina of maxillary tooth at slightly later stage of development.
TS21: upper jaw tooth mesenchyme Present Regionally restricted 2B No expression in underlying ectomesenchymal condensation, which will form dental follicle and papilla. Strong expression in surrounding ectomesenchyme.

Specimen 2C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: otic capsule Absent 2C
TS21: ear mesenchyme Present Regionally restricted 2C Marked expression in surrounding ectomesenchyme.
TS21: perioptic mesenchyme Present 2C Marked expression in periocular mesenchyme.
TS21: neural retina Absent 2C


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory