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Gene Expression Data
Assay Details
Assay
Reference: J:266915 Bonet F, et al., CCBE1 is required for coronary vessel development and proper coronary artery stem formation in the mouse heart. Dev Dyn. 2018 Oct;247(10):1135-1145
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6270387
Gene symbol: Dach1
Gene name: dachshund family transcription factor 1
Antibody: anti-DACH1
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 3A WT: embryonic day 13.5 (more )
Note: Double labeled: red - Dach1; green - Cdh5 (assay MGI:6270371).
Structure Level Pattern Image Note
TS21: coronary artery Present 3A lower left , 3A upper left
Specimen 3A KO: embryonic day 13.5; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Note: Double labeled: red - Dach1; green - Cdh5 (assay MGI:6270371).
Structure Level Pattern Image Note
TS21: coronary artery Present Regionally restricted 3A upper right , 3A lower right Severely underdeveloped dorsal intramyocardial coronary vessels were stunted in mutant hearts.
Specimen 4A WT: embryonic day 14.0 (more )
Note: Double labeled: red - Dach1; green - Cdh5 (assay MGI:6270371).
Structure Level Pattern Image Note
TS22: coronary artery Present 4A upper left , 4A lower left
Specimen 4A KO: embryonic day 14.0; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Note: Double labeled: red - Dach1; green - Cdh5 (assay MGI:6270371).
Structure Level Pattern Image Note
TS22: coronary artery Present Regionally restricted 4A upper right , 4A lower right Ventral intramyocardial coronary vessels were underdeveloped in mutant hearts.
Specimen 4C WT: embryonic day 14.0 (more )
Note: Double labeled: red - Dach1; green - Cdh5 (assay MGI:6270371).
Structure Level Pattern Image Note
TS22: coronary artery Present 4C lower left , 4C upper left
Specimen 4C KO: embryonic day 14.0; Ccbe1tm1Lex/Ccbe1tm1Lex (more )
Note: Double labeled: red - Dach1; green - Cdh5 (assay MGI:6270371).
Structure Level Pattern Image Note
TS22: coronary artery Present Regionally restricted 4C upper right , 4C lower right Fewer subepicardial and intramyocardial coronary vessels in mutant hearts.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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