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Gene Expression Data
Assay Details
Assay
Reference: J:264553 Tarchini B, et al., A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development. Dev Biol. 2018 Nov 15;443(2):153-164
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6258747
Gene symbol: Nr2f1
Gene name: nuclear receptor subfamily 2, group F, member 1
Antibody: COUP-TF/NR2F1 antibody (H8132)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 3B +/dwnd: embryonic day 16.5; Mctp1dwnd/Mctp1+ (more )
Note: Triple labeled: red - Nr2f1; green - Sox2 (assay MGI:6258748); blue - DAPI.
Structure Level Pattern Image Note
TS24: cochlea Present Regionally restricted 3B +/dwnd lower , 3B +/dwnd upper Broadly expressed in cochlear floor, overlapping Sox2 expression in prosensory domain, but also extending more neurally.
Specimen 3B dwnd/dwnd: embryonic day 16.5; Mctp1dwnd/Mctp1dwnd (more )
Note: Triple labeled: red - Nr2f1; green - Sox2 (assay MGI:6258748); blue - DAPI.
Structure Level Pattern Image Note
TS24: cochlea Weak Regionally restricted 3B dwnd/dwnd upper , 3B dwnd/dwnd lower Authors report expression in cochlear floor was severely reduced in homozygote compared to heterozygote control. Expression retained in abneural cells in the sensory domain, and non-epithelial cells outside the cochlear duct.
Specimen 3C +/dwnd: embryonic day 16.5; Mctp1dwnd/Mctp1+ (more )
Note: Double labeled: red - Nr2f1; green - Sox2 (assay MGI:6258748).
Structure Level Pattern Image Note
TS24: retina Present 3C +/dwnd lower , 3C +/dwnd upper
Specimen 3C dwnd/dwnd: embryonic day 16.5; Mctp1dwnd/Mctp1dwnd (more )
Note: Double labeled: red - Nr2f1; green - Sox2 (assay MGI:6258748).
Structure Level Pattern Image Note
TS24: retina Present 3C dwnd/dwnd upper , 3C dwnd/dwnd lower Authors report expression in retina enriched in a comparable manner in homozygotes as in heterozygote control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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