Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Wnk4tm3.1Suc
Name:	WNK lysine deficient protein kinase 4; targeted mutation 3.1, Shinchi Uchida
MGI ID:	MGI:6214838
Synonyms:	WNK4-
Gene:	Wnk4  Location: Chr11:101151393-101168235 bp, + strand  Genetic Position: Chr11, 64.51 cM
Alliance:	Wnk4tm3.1Suc page

Germline Transmission:	Earliest citation of germline transmission: J:241978
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2 and a FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 2. Cre-mediated recombination deleted exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein in kidney. (J:241978)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk4 Mutation:	56 strains or lines available

Original:	J:241978 Takahashi D, et al., WNK4 is the major WNK positively regulating NCC in the mouse kidney. Biosci Rep. 2014 May 09;34(3):e00107
All:	3 reference(s)