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Gene Expression Data
Assay Details
Assay
Reference: J:150375 Cobourne MT, et al., Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome. Dev Biol. 2009 Jul 1;331(1):38-49
Assay type: RNA in situ
MGI Accession ID: MGI:6209776
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh cDNA3
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 7B: embryonic day 13.5 (more )
Note: Bud stage.
Structure Level Pattern Image Note
TS21: molar epithelium Present Regionally restricted 7B Restricted and localized expression in epithelial compartment of tooth germ. Expression downregulated at tip of mature bud.
Specimen 7L: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: enamel knot Present Regionally restricted 7L Expression restricted to enamel knot.
TS22: molar Present Regionally restricted 7L Expression restricted to enamel knot.
Specimen 8B: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: enamel knot Strong Regionally restricted 8B Strong expression in epithelial enamel knots.
TS22: incisor Strong Regionally restricted 8B Strong expression in epithelial enamel knots.
Specimen 8J: embryonic day 15.5 (more )
Note: Late cap stage.
Structure Level Pattern Image Note
TS23: enamel knot Present Regionally restricted 8J Expression restricted to enamel knots.
TS23: incisor Present Regionally restricted 8J Expression restricted to enamel knots.
Specimen 8R: embryonic day 16.5 (more )
Note: Early bell stage.
Structure Level Pattern Image Note
TS24: incisor epithelium Weak Regionally restricted 8R Reduced expression in epithelium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory