Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cr2tm1(CR2,CR1)How
Name:	complement receptor 2; targeted mutation 1, Gareth Howell
MGI ID:	MGI:6202941
Gene:	Cr2  Location: Chr1:194819119-194859024 bp, - strand  Genetic Position: Chr1, 98.44 cM
Alliance:	Cr2tm1(CR2,CR1)How page

Germline Transmission:	Earliest citation of germline transmission: J:296605
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Cr2tm1(CR2,CR1)How expresses 2 genes Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human CR1 (1378) Cr1l  (MGI:88513) human CR2 (1380) Cr2  (MGI:88489)   Mutation details: A targeting vector containing human CR2, complement C3d receptor 2, gene sequence with an attB-PGKneo-attP cassette in intron 19, followed by the intergenic region between the human CR2 and CR1 genes, and human CR1, complement C3b/C4b receptor 1 (Knops blood group), gene sequence (with a loxP site inserted into intron 3, a FRT site inserted into intron 12, and loxP and FRT sites inserted into intron 20), was inserted at the ATG initiation codon of the mouse Cr2 gene. The CR1 gene sequence has exons 4 through 20 flanked by loxP sites and exon 13 through 20 flanked by FRT sites. Recombination removed the selection cassette. (J:296605)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cr2 Mutation:	84 strains or lines available

Original:	J:296605 Jackson HM, et al., A novel mouse model expressing human forms for complement receptors CR1 and CR2. BMC Genet. 2020;21(101)
All:	1 reference(s)