Gene Expression Data
Assay Details
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Assay
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Reference:
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J:57646
Wigle JT, et al., Prox1 function is required for the development of the murine lymphatic system. Cell. 1999 Sep 17;98(6):769-78
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6201337
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Gene symbol:
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Flt4
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Gene name:
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FMS-like tyrosine kinase 4
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Results
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Specimen
6F:
embryonic day 12.5; Prox1tm1Gco/Prox1 +
(more  )
Specimen
6F:
(close  )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * NMRI
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Mutant Allele(s):
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Prox1tm1Gco/Prox1+
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: lymphatic system |
Strong |
Regionally restricted |
6F
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Strong expression in a subpopulation of cells in vicinity of cardinal vein - corresponding to lymphatic endothelial cells.
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| TS20: blood vessel endothelium |
Weak |
Regionally restricted |
6F
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Weak expression in vascular endothelial cells.
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Specimen
6H:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * NMRI
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Mutant Allele(s):
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Prox1tm1Gco/Prox1tm1Gco
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: lymphatic system |
Ambiguous |
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6H
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Authors state no strongly labeled cells were found, supporting the concept of arrested lymphatic vasculature development
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| TS20: blood vessel endothelium |
Weak |
Regionally restricted |
6H
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Weak expression in vascular endothelial cells.
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Specimen
E14.5 not shown:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * NMRI
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Mutant Allele(s):
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Prox1tm1Gco/Prox1tm1Gco
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: lymphatic system |
Ambiguous |
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No strong expression in E14.5 homozygous embryos.
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Analysis Tools
