Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Sox10-cre/ERT2)1Sout
Name:	transgene insertion 1, E Southard-Smith
MGI ID:	MGI:6201041
Synonyms:	Sox10-CreERT2
Transgene:	Tg(Sox10-cre/ERT2)1Sout  Location: unknown
Alliance:	Tg(Sox10-cre/ERT2)1Sout page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Sox10-cre/ERT2)1Sout expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Sox10 (MGI:98358)   Mutation details: Using the BAC containing Sox10 regulatory regions, a Cre recombinase coding region fused with a mutated ligand-binding domain of the human estrogen receptor (ERT2) was inserted directly downstream of the transcription initiation site. LoxP sites in the BAC flanking arms were removed prior to microinjection. The Sox10 regulatory regions drive neural crest-specific expression of CreERT2 recombinase. (J:299312)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox10 (mouse) Summary of all recombinase alleles driven by Sox10. Alliance mouse Sox10 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:299312 Deal KK, et al., Sox10-cre BAC transgenes reveal temporal restriction of mesenchymal cranial neural crest and identify glandular Sox10 expression. Dev Biol. 2020;471:119-13
All:	1 reference(s)