Ighe<DSP2.7/8-JH1Durw> Allele Detail MGI Mouse (MGI:6195834)

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Ighe^{DSP2.7/8-JH1Durw}
Allele Detail

Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Summary

Symbol:	Ighe^{DSP2.7/8-JH1Durw}
Name:	Immunoglobulin heavy constant epsilon; DSP2.7/8-JH1, Duane R Wesemann
MGI ID:	MGI:6195834
Gene:	Ighe Location: Chr12:113232883-113236868 bp, - strand Genetic Position: Chr12, 62.1 cM
Alliance:	Ighe^{DSP2.7/8-JH1Durw} page

Mutation
origin

Strain of Origin:

(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:		Other (Not Applicable)
Mutation:		Other
		Mutation details: A mature B cell, where the the immunoglobulin heavy chain complex had undergone Igh-D to Ighj1 recombination and subsequently an IgE class-switch, was isolated and reprogrammed to an iPSC (induced pluripotent stem cell). This iPSC was then used to create a homozygous mouse line where all cells contain this non-productive allele. The mouse from which the B cells were isolated is a reprogrammable mouse containing the Col1a1^{tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch} and Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} alleles which allow for the reprogramming to be induced by doxycycline. Sequencing of the DJ junction could not distinguish between the recombination involving DSP2.7 (Ighd2-1102) or DSP2.8 (Ighd2-1002). (J:252910*)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ighe Mutation:	24 strains or lines available

References

Original:	J:252910 Tong P, et al., IgH isotype-specific B cell receptor expression influences B cell fate. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8411-E8420
All:	1 reference(s)

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