Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Fustm3.1(FUS)Emcf
Name:	fused in sarcoma; targeted mutation 3.1, Elizabeth MC Fisher
MGI ID:	MGI:6193752
Gene:	Fus  Location: Chr7:127565276-127581204 bp, + strand  Genetic Position: Chr7, 69.87 cM
Alliance:	Fustm3.1(FUS)Emcf page

Germline Transmission:	Earliest citation of germline transmission: J:342505
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: The endogenous mouse gene was targeted using the RP24-297F14 bacterial artificial chromosome (BAC), from the RPCI-24 mouse genomic library derived from a C57BL/6J male mouse, in which the sequence from the translation initiation site through the 3' untranslated region (3'-UTR) had been replaced by the orthologous human sequence. A single FRT site ~1 kb downstream of the humanized 3'-UTR marks the location of a neomycin resistance cassette that has been removed by Flp recombinase. (J:342505)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fus Mutation:	39 strains or lines available

Original:	J:342505 Devoy A, et al., Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. iScience. 2021 Dec 17;24(12):103463
All:	2 reference(s)