Fustm3.1(FUS)Emcf
Targeted Allele Detail
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| Symbol: |
Fustm3.1(FUS)Emcf |
| Name: |
fused in sarcoma; targeted mutation 3.1, Elizabeth MC Fisher |
| MGI ID: |
MGI:6193752 |
| Gene: |
Fus Location: Chr7:127565276-127581204 bp, + strand Genetic Position: Chr7, 69.87 cM
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| Alliance: |
Fustm3.1(FUS)Emcf page
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| Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The endogenous mouse gene was targeted using the RP24-297F14 bacterial artificial chromosome (BAC), from the RPCI-24 mouse genomic library derived from a C57BL/6J male mouse, in which the sequence from the translation initiation site through the 3' untranslated region (3'-UTR) had been replaced by the orthologous human sequence. A single FRT site ~1 kb downstream of the humanized 3'-UTR marks the location of a neomycin resistance cassette that has been removed by Flp recombinase.
(J:342505)
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| Original: |
J:342505 Devoy A, et al., Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. iScience. 2021 Dec 17;24(12):103463 |
| All: |
3 reference(s) |
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Analysis Tools
