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Gene Expression Data
Assay Details
Assay
Reference: J:135997 Nie X, et al., Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol. 2008 Apr 15;316(2):417-30
Assay type: RNA in situ
MGI Accession ID: MGI:6193720
Gene symbol: Msx2
Gene name: msh homeobox 2
Probe: Msx2 probe36
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 6C: embryonic day 9.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch Strong 6C
TS15: 2nd branchial arch Strong 6C
Specimen 6D: embryonic day 9.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: 1st branchial arch Weak 6D Expression was visibly reduced but not eliminated.
TS15: 2nd branchial arch Weak 6D Expression was visibly reduced but not eliminated.
Specimen 7E: embryonic day 10.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS17: head Present 7E
Specimen 7F: embryonic day 10.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: head Weak Regionally restricted 7F Authors report markedly reduced expression in facial primordia at E10.5
Specimen 7G: embryonic day 11.0; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component Present 7G Authors report robust expression in mandibular, maxillary and frontonasal prominences.
TS18: 1st branchial arch maxillary component Present 7G Authors report robust expression in mandibular, maxillary and frontonasal prominences.
TS18: fronto-nasal process Present 7G Authors report robust expression in mandibular, maxillary and frontonasal prominences.
Specimen 7H: embryonic day 11.0; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component Absent 7H Expression was absent from mandibular and maxillary prominences.
TS18: 1st branchial arch maxillary component Absent 7H Expression was absent from mandibular and maxillary prominences.
TS18: fronto-nasal process Present 7H Expression still present in frontonasal prominences.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory