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Gene Expression Data
Assay Details
Assay
Reference: J:135997 Nie X, et al., Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol. 2008 Apr 15;316(2):417-30
Assay type: RNA in situ
MGI Accession ID: MGI:6193718
Gene symbol: Msx1
Gene name: msh homeobox 1
Probe: Msx1 probe36
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 5C: embryonic day 8.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS13: embryo Present 5C
Specimen 5D: embryonic day 8.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: embryo Present 5D Authors report no obvious abnormal expression.
Specimen 6A: embryonic day 9.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch Strong 6A
TS15: 2nd branchial arch Strong 6A
Specimen 6B: embryonic day 9.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: 1st branchial arch Weak 6B Expression was visibly reduced but not eliminated.
TS15: 2nd branchial arch Weak 6B Expression was visibly reduced but not eliminated.
Specimen 7A: embryonic day 10.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS17: head Present 7A
Specimen 7B: embryonic day 10.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: head Weak Regionally restricted 7B Authors report markedly reduced expression in facial primordia at E10.5
Specimen 7C: embryonic day 11.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS19: fronto-nasal process Strong 7C Authors report robust expression in mandibular, maxillary and frontonasal prominences.
TS19: mandibular process Strong 7C Authors report robust expression in mandibular, maxillary and frontonasal prominences.
TS19: maxillary process Strong 7C Authors report robust expression in mandibular, maxillary and frontonasal prominences.
Specimen 7D: embryonic day 11.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: mandibular process Absent 7D Expression was absent from mandibular and maxillary prominences.
TS19: maxillary process Absent 7D Expression was absent from mandibular and maxillary prominences.
TS19: fronto-nasal process Present 7D Expression was absent from mandibular and maxillary prominences.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory