About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:135997 Nie X, et al., Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol. 2008 Apr 15;316(2):417-30
Assay type: RNA in situ
MGI Accession ID: MGI:6193717
Gene symbol: Tfap2a
Gene name: transcription factor AP-2, alpha
Probe: Ap-2 probe8
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 5A: embryonic day 8.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS13: embryo Present 5A
Specimen 5B: embryonic day 8.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: embryo Present 5B Authors report no obvious abnormal expression.
Specimen 6I: embryonic day 9.5; Smad4tm2.1Cxd/Smad4+ (more )
Structure Level Pattern Image Note
TS15: branchial arch Moderate Widespread 6I Moderately expression in all pharyngeal arches and neural crest cell migration streams.
TS15: migrating neural crest Moderate Widespread 6I Moderately expression in all pharyngeal arches and neural crest cell migration streams.
Specimen 6J: embryonic day 9.5; Smad4tm2.1Cxd/Smad4tm2.1Cxd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: branchial arch Weak 6J Expression clearly reduced in mutants.
TS15: migrating neural crest Weak 6J Expression clearly reduced in mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory