Epn1<tm1Wami> Targeted Allele Detail MGI Mouse (MGI:6188830)

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Epn1^tm1Wami
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Summary

Symbol:	Epn1^tm1Wami
Name:	epsin 1; targeted mutation 1, Wang Min
MGI ID:	MGI:6188830
Synonyms:	Epn1^fl
Gene:	Epn1 Location: Chr7:5083234-5101177 bp, + strand Genetic Position: Chr7, 2.94 cM
Alliance:	Epn1^tm1Wami page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. (J:193966)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Epn1 Mutation:	32 strains or lines available

Notes

The version of this allele that does not contain the neomycin selection cassette, Epn1^tm1.1Wami, has been analyzed.

References

Original:	J:193966 Pasula S, et al., Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec 3;122(12):4424-38
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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