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Gene Expression Data
Assay Details
Assay
Reference: J:256989 King R, et al., Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. PLoS Genet. 2018 Jan;14(1):e1007145
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6187963
Gene symbol: Pou6f2
Gene name: POU domain, class 6, transcription factor 2
Antibody: anti-POU6F2
Detection system: Alexa Fluor 488
Results
Specimen 6A: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: neural retina Strong Regionally restricted 6A Prominent expression in neuroblasts destined to become retinal ganglion cells.
TS24: cornea epithelium Present Regionally restricted 6A Expression in corneal epithelium and corneal stem cells.
Specimen ganglion cell layer: postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present Expression in many cells in ganglion cell layer.
Specimen 7A/D: postnatal adult (more )
Note: Flat mount. Triple labeled: green - Pou6f2; red - Rbpms (assay MGI:6187964); blue - TOPRO-3.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 7D , 7A Authors report expression in only a small percentage of total number of cells in ganglion cell layer.
Specimen Young D2: postnatal month 2 (more )
Note: Data shown in Figure 8.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present
Specimen Aged D2: postnatal month 8 (more )
Note: Data shown in Figure 8.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Weak Authors report a 73% loss of expressing retinal ganglion cells (RGCs) in aged DBA/2J mice compared to young DBA/2J mice.
Specimen cornea and sclera: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cornea Absent
TS28: sclera Absent
Specimen 9A: postnatal adult (more )
Note: Flat mount.
Structure Level Pattern Image Note
TS28: corneo-scleral junction Present 9A Expression in line of cells at junction of cornea and sclera.
Specimen 9D/F: postnatal adult (more )
Note: Flat mount. Triple labeled: green - Pou6f2; red - Abcb5 (assay MGI:6187965); blue - TOPRO-3.
Structure Level Pattern Image Note
TS28: corneo-scleral junction Present 9D , 9F Expression in many cells in the limbus.
Specimen S4A: postnatal adult (more )
Note: Flat mount.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present S4A
Specimen S4B: postnatal adult (more )
Note: Flat mount.
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted S4B Expression in amacrine cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory