Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Col15a1tm2.1Pih
Name:	collagen, type XV, alpha 1; targeted mutation 2.1, Taina Pihlajaniemi
MGI ID:	MGI:6147361
Synonyms:	loxP flanked allele
Gene:	Col15a1  Location: Chr4:47208161-47313167 bp, + strand  Genetic Position: Chr4, 26.01 cM, cytoband B1-B3
Alliance:	Col15a1tm2.1Pih page

Germline Transmission:	Earliest citation of germline transmission: J:82809
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A loxP site was introduced ~900 bp upstream of exon 1 and a loxP-flanked neomycin resistance cassette 120 bp downstream of exon 2. Cre recombinase deleted the selection cassette, leaving exons 1 and 2, encoding the first 33 amino acids of the protein, flanked by loxP sites. This allele was derived from the same targeting event as Col15a1tm1Pih. (J:67212)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col15a1 Mutation:	71 strains or lines available

Original:	J:67212 Eklund L, et al., Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1194-9
All:	2 reference(s)