Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(CRY2*A260T)24Ljp
Name:	transgene insertion 24, Louis Ptacek
MGI ID:	MGI:6121037
Synonyms:	hCRY2-A260T
Transgene:	Tg(CRY2*A260T)24Ljp  Location: unknown
Alliance:	Tg(CRY2*A260T)24Ljp page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(CRY2*A260T)24Ljp expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CRY2 (1408) Cry2  (MGI:1270859) Expresses an A260T mutation   Mutation details: The transgenic construct contains human BAC RP11-1084E2, encoding full-length CRY2 and incorporating an A260T (amino acid)/GAACGCCA to GAACACCA (nucleotide) mutation. Founder line 24 carries 15 copies of the transgene. The A260T missense mutation was identified in one family affected with Familial Advanced Sleep Phase (FASP). The mutation is located in the phosphate loop of the flavin adenine dinucleotide (FAD) binding domain. (J:257412)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:257412 Hirano A, et al., A Cryptochrome 2 mutation yields advanced sleep phase in humans. Elife. 2016 Aug 16;5:e16695
All:	1 reference(s)