Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rr45tm1.1Tshir
Name:	regulatory region 45; targeted mutation 1.1, Toshihiko Shiroishi
MGI ID:	MGI:6117321
Synonyms:	deltaMFCS4, MFCS4-
Gene:	Rr45  Location: unknown  Genetic Position: Chr5, Syntenic
Alliance:	Rr45tm1.1Tshir page

Germline Transmission:	Earliest citation of germline transmission: J:148018
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutations:    Insertion, Intragenic deletion   Rr45tm1.1Tshir involves 1 genes/genome features (Rnf32) View all   Mutation details: A neomycin resistance gene cassette replaced 1 kb including the MFCS4 (mammals-fish conserved sequence 4) enhancer of Shh located within intron 8 of Rnf32. (J:148018)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rr45 Mutation:	2 strains or lines available

Original:	J:148018 Sagai T, et al., A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
All:	4 reference(s)