All Phenotypes Rr45<tm1.1Tshir> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr45^tm1.1Tshir
targeted mutation 1.1, Toshihiko Shiroishi
MGI:6117321

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr45^tm1.1Tshir/Rr45^tm1.1Tshir	involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj	MGI:6144004
cx2	Rr45^tm1.1Tshir/Rr45⁺ Shh^tm1Chg/Shh⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/JNCrlj	MGI:6144003

Allelic Composition	Rr45^tm1.1Tshir/Rr45^tm1.1Tshir
Genetic Background	involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr45^tm1.1Tshir mutation (2 available); any Rr45 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:148018 )

• all mice die within a few days of birth

craniofacial

abnormal basioccipital bone morphology ( J:148018 )

• minor abnormalities

abnormal sphenoid bone morphology ( J:148018 )

• cartilage contains a hole likely the pituitary fossa

abnormal basisphenoid bone morphology ( J:148018 )

• minor abnormalities

abnormal hyoid bone morphology ( J:148018 )

short soft palate ( J:148018 )

cleft palate ( J:148018 )

• in 5 of 37 mice

abnormal tongue morphology ( J:148018 )

growth/size/body

abnormal hyoid bone morphology ( J:148018 )

short soft palate ( J:148018 )

cleft palate ( J:148018 )

• in 5 of 37 mice

abnormal tongue morphology ( J:148018 )

abnormal epiglottis morphology ( J:148018 )

• loss or reduced size

meteorism ( J:148018 )

• air in stomach and bowels

digestive/alimentary system

short soft palate ( J:148018 )

cleft palate ( J:148018 )

• in 5 of 37 mice

abnormal tongue morphology ( J:148018 )

abnormal epiglottis morphology ( J:148018 )

• loss or reduced size

meteorism ( J:148018 )

• air in stomach and bowels

behavior/neurological

absent gastric milk in neonates ( J:148018 )

respiratory system

abnormal epiglottis morphology ( J:148018 )

• loss or reduced size

abnormal arytenoid cartilage morphology ( J:148018 )

• hypotrophy

abnormal thyroid cartilage morphology ( J:148018 )

abnormal pharynx morphology ( J:148018 )

skeleton

abnormal basioccipital bone morphology ( J:148018 )

• minor abnormalities

abnormal sphenoid bone morphology ( J:148018 )

• cartilage contains a hole likely the pituitary fossa

abnormal basisphenoid bone morphology ( J:148018 )

• minor abnormalities

abnormal hyoid bone morphology ( J:148018 )

abnormal epiglottis morphology ( J:148018 )

• loss or reduced size

abnormal arytenoid cartilage morphology ( J:148018 )

• hypotrophy

abnormal thyroid cartilage morphology ( J:148018 )

Allelic Composition	Rr45^tm1.1Tshir/Rr45⁺ Shh^tm1Chg/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr45^tm1.1Tshir mutation (2 available); any Rr45 mutation (2 available)
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

epiglottis hypoplasia ( J:148018 )

abnormal arytenoid cartilage morphology ( J:148018 )

respiratory system

epiglottis hypoplasia ( J:148018 )

abnormal arytenoid cartilage morphology ( J:148018 )

digestive/alimentary system

epiglottis hypoplasia ( J:148018 )

growth/size/body

epiglottis hypoplasia ( J:148018 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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