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Gene Expression Data
Assay Details
Assay
Reference: J:45117 Southard-Smith EM, et al., Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat Genet. 1998 Jan;18(1):60-4
Assay type: RNA in situ
MGI Accession ID: MGI:6095203
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Probe: Sox10 ISH probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2a: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: migrating neural crest Present 2a
TS15: trigeminal preganglion Present 2a
Specimen 2b: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: glossopharyngeal-vagus preganglion complex Present 2b
TS15: migrating neural crest Present 2b
Specimen 2c: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present 2c
TS15: peripheral nervous system Present 2c
Specimen 2d: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: migrating neural crest Present Regionally restricted 2d Expression is in migrating sacral neural crest in the tail.
Specimen 2e: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: cranial ganglion Present 2e
TS19: dorsal root ganglion Present 2e
TS19: sympathetic ganglion Present 2e
Specimen 2f: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: sympathetic ganglion Present 2f
TS20: enteric nervous system Present Regionally restricted 2f Expression is in enteric ganglia.
Specimen 2g: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 2g
TS20: skin Present Regionally restricted 2g Expression is in presumptive melanoblasts.
Specimen 2h: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: enteric nervous system Present Regionally restricted 2h Expression is in myenteric ganglia.
Specimen 2i: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: skin Present Regionally restricted 2i Expression is in the dorsolateral melanoblast migratory pathway.
Specimen 5a +/+: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Present 5a +/+
TS17: dorsal root ganglion Present 5a +/+
TS17: migrating neural crest Present 5a +/+
Specimen 5a Dom/Dom: embryonic day 10.5; Sox10Dom/Sox10Dom (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Present 5a Dom/Dom Expression is disrupted and delayed in this mutant compared to wild-type embryos.
TS17: migrating neural crest Present 5a Dom/Dom Expression is disrupted and delayed in this mutant compared to wild-type embryos.
TS17: cranial ganglion Weak 5a Dom/Dom
Specimen not shown +/+ E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: neural crest Present
Specimen not shown Dom/Dom E9.5: embryonic day 9.5; Sox10Dom/Sox10Dom (more )
Structure Level Pattern Image Note
TS15: neural crest Present Expression in this mutant is the same as in wild-type embryos.
Specimen not shown +/+ E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: migrating neural crest Present
Specimen not shown Dom/Dom/ E11.5: embryonic day 11.5; Sox10Dom/Sox10Dom (more )
Structure Level Pattern Image Note
TS19: migrating neural crest Present Regionally restricted Expression is found only in the most caudal neural crest cells of the tail.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory