Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Sox10-icre/ERT2)93Vpa
Name:	transgene insertion 93, Vassilis Pachnis
MGI ID:	MGI:5910373
Synonyms:	Sox10::CreERT2 (SER93), Sox10::iCreERT2
Transgene:	Tg(Sox10-icre/ERT2)93Vpa  Location: unknown
Alliance:	Tg(Sox10-icre/ERT2)93Vpa page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Sox10-icre/ERT2)93Vpa expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Sox10 (MGI:98358)   Mutation details: The coding sequence of Sox10 in a phage artificial chromosome (PAC; RP21-529-16) was replaced with an icre/ERT2 cassette by homologous recombination in bacteria. The targeting vector also contained an Frt-flanked chloramphenicol resistance gene, which was removed by transient activation of Flp in bacteria. A construct was generated that encodes tamoxifen-inducible cre under control of the Sox10 regulatory sequences. The purified targeting construct was used to generate transgenic mice. These animals were crossed to ROSA26-EYFP reporter animals for analysis. Data for line 26 (SER26, [S]ox10::icre[ER]T2) was presented and was also confirmed by analysis of lines 68, 87, and 93. (J:178239)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox10 (mouse) Summary of all recombinase alleles driven by Sox10. Alliance mouse Sox10 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:178239 Laranjeira C, et al., Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J Clin Invest. 2011 Sep 1;121(9):3412-24
All:	10 reference(s)