Tg(Ins1-Foxm1/GH1)#Dabd
Transgene Detail
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| Symbol: |
Tg(Ins1-Foxm1/GH1)#Dabd |
| Name: |
transgene insertion, Dawn Belt Davis |
| MGI ID: |
MGI:5910279 |
| Synonyms: |
FoxM1-hGH |
| Transgene: |
Tg(Ins1-Foxm1/GH1)#Dabd Location: unknown
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| Alliance: |
Tg(Ins1-Foxm1/GH1)#Dabd page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Ins1-Foxm1/GH1)#Dabd expresses
1 gene
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Mutation details: A vector containing the following elements was injected into pronuclei of the host embryos: mouse promoter, Kozak sequence, the mouse cDNA, 29 bp Myc tag, two stop codons, Kozak sequence and the human growth hormone 1 minigene. Zygotes were isolated from BTBR (Black and Tan Brachyury) females. BTBR mice are models for the study of type 2 diabetes (T2DM) and autism spectrum disorder (ASD) and carry the Disc1del, Itpr3tf and T+ alleles. The human gene confers high levels of expression of this allele. Expression of the mouse gene was confirmed by RT-PCR, but unintended expression of the human gene was also shown. Likewise, both the mouse and human proteins were detected. The pound symbol (#) is used when no line is specified.
(J:227290)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:227290 Baan M, et al., Transgenic expression of the human growth hormone minigene promotes pancreatic beta-cell proliferation. Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R788-94 |
| All: |
2 reference(s) |
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Analysis Tools
