Disc1<del> Spontaneous Allele Detail MGI Mouse (MGI:3623217)

Disc1^del
Spontaneous Allele Detail

Summary

Symbol:	Disc1^del
Name:	disrupted in schizophrenia 1; deletion
MGI ID:	MGI:3623217
Synonyms:	Disc1^129S6, Disc1^delta6
Gene:	Disc1 Location: Chr8:125780934-125988597 bp, + strand Genetic Position: Chr8, 73.26 cM
Alliance:	Disc1^del page

Mutation
origin

Strain of Origin:

various

Mutation
description

Allele Type:		Spontaneous
Mutation:		Intragenic deletion
		Mutation details: A 25 bp deletion in exon 6 causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon in exon 7. (J:107244)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 19 strains available Cell Lines: 0 lines available
Carrying any Disc1 Mutation:	69 strains or lines available

Notes

This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T⁺ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).

References

Original:	J:107244 Koike H, et al., Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3693-7
All:	13 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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