About   Help   FAQ
Apoeem2(APOE*)Adiuj
Endonuclease-mediated Allele Detail
Summary
Symbol: Apoeem2(APOE*)Adiuj
Name: apolipoprotein E; endonuclease-mediated mutation 1, MODEL-AD Center
MGI ID: MGI:5907023
Synonyms: APOEepsilon3
Gene: Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance: Apoeem2(APOE*)Adiuj page
Mutation
origin
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Apoeem2(APOE*)Adiuj expresses 1 gene
 
Mutation detailsCRISPR-Cas9 methodology introduced a R130C point mutation into the human APOE protein carried by the Apoetm1.1(APOE*4)Adpmc allele. (J:323137)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  146 strains or lines available
References
Original:  J:323137 Foley KE, et al., The APOE (epsilon3/epsilon4) Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice. Front Aging Neurosci. 2022;14:838436
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory