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Gene Expression Data
Assay Details
Assay
Reference: J:16077 Schneider-Maunoury S, et al., Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell. 1993 Dec 17;75(6):1199-214
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5823215
Gene symbol: Egr2
Gene name: early growth response 2
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 8.0; Egr2tm1Pch/Egr2+ (more )
Note: 0-3 somites
Structure Level Pattern Image Note
TS12: anterior pro-rhombomere Present Regionally restricted 2A Expression is in the future rhombomere 3.

Specimen 2B: embryonic day 8.0; Egr2tm1Pch/Egr2tm1Pch (more )
Note: 0-3 somites
Structure Level Pattern Image Note
TS12: anterior pro-rhombomere Present Regionally restricted 2B Expression is in the future rhombomere 3.

Specimen 2C: embryonic day 9.0; Egr2tm1Pch/Egr2+ (more )
Note: 10-13 somites
Structure Level Pattern Image Note
TS14: rhombomere 3 Present 2C
TS14: rhombomere 5 Present 2C

Specimen 2D: embryonic day 9.0; Egr2tm1Pch/Egr2tm1Pch (more )
Note: 10-13 somites
Structure Level Pattern Image Note
TS14: rhombomere 5 Present 2D
TS14: rhombomere 3 Trace 2D

Specimen 2E: embryonic day 9.5; Egr2tm1Pch/Egr2+ (more )
Structure Level Pattern Image Note
TS15: rhombomere 5 Strong 2E
TS15: rhombomere 3 Weak 2E
TS15: migrating neural crest Present Regionally restricted 2E Expression is in a population of cells posterior to rhombomere 5 that corresponds to migrating neural crest cells into the third branchial arch.

Specimen 2F: embryonic day 9.5; Egr2tm1Pch/Egr2tm1Pch (more )
Structure Level Pattern Image Note
TS15: rhombomere 5 Weak 2F
TS15: rhombomere 3 Trace 2F
TS15: migrating neural crest Present Regionally restricted 2F Expression is in a population of cells anterior and posterior to rhombomere 5, the latter corresponds to migrating neural crest cells into the third branchial arch.

Specimen 2G: embryonic day 10.5; Egr2tm1Pch/Egr2+ (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Present Regionally restricted 2G Expression is at the boundary gap cells.
TS17: spinal nerve Present Regionally restricted 2G Expression is in sensory and motor roots of spinal nerves and in the portion of nerve XI in close proximity to the central nervous system.
TS17: rhombomere 5 Trace 2G

Specimen 2H: embryonic day 10.5; Egr2tm1Pch/Egr2tm1Pch (more )
Structure Level Pattern Image Note
TS17: acoustic ganglion Present Regionally restricted 2H Expression is at the nearly fused boundary gap cells of nerves V and VII/VIII.
TS17: facial ganglion Present Regionally restricted 2H Expression is at the nearly fused boundary gap cells of nerves V and VII/VIII.
TS17: trigeminal ganglion Present Regionally restricted 2H Expression is at the nearly fused boundary gap cells of nerves V and VII/VIII.
TS17: spinal nerve Present Regionally restricted 2H Expression is in motor roots of spinal nerves and in the portion of nerve XI in close proximity to the central nervous system.

Specimen 3A: embryonic day 8.5; Egr2tm1Pch/Egr2+ (more )
Structure Level Pattern Image Note
TS13: migrating neural crest Present Regionally restricted 3A Expression is in a population of cells posterior to rhombomere 5 that corresponds to migrating neural crest cells into the third branchial arch.
TS13: anterior pro-rhombomere Present Regionally restricted 3A Expression is in rhombomere 3 and 5.

Specimen 3B: embryonic day 8.5; Egr2tm1Pch/Egr2tm1Pch (more )
Structure Level Pattern Image Note
TS13: migrating neural crest Present Regionally restricted 3B Expression is in a population of cells anterior and posterior to rhombomere 5, the latter corresponds to migrating neural crest cells into the third branchial arch.
TS13: anterior pro-rhombomere Present Regionally restricted 3B Expression is in rhombomere 5.

Specimen 3C: embryonic day 9.5; Egr2tm1Pch/Egr2+ (more )
Structure Level Pattern Image Note
TS15: rhombomere 5 Strong 3C
TS15: rhombomere 3 Weak 3C

Specimen 3D: embryonic day 9.5; Egr2tm1Pch/Egr2tm1Pch (more )
Structure Level Pattern Image Note
TS15: rhombomere 5 Weak Regionally restricted 3D Expression is in a small area adjacent to the rostral part of the otic vesicle.

Specimen 3E: embryonic day 10.5; Egr2tm1Pch/Egr2+ (more )
Structure Level Pattern Image Note
TS17: rhombomere 5 Present 3E
TS17: acoustic ganglion Present Regionally restricted 3E Expression is in boundary gap cells.
TS17: cranial ganglion Present Regionally restricted 3E Expression is in boundary gap cells.
TS17: trigeminal ganglion Present Regionally restricted 3E Expression is in boundary gap cells.

Specimen 3F: embryonic day 10.5; Egr2tm1Pch/Egr2tm1Pch (more )
Structure Level Pattern Image Note
TS17: acoustic ganglion Present Regionally restricted 3F Expression is in the nerve plexus that corresponds to a fusion of these ganglia.
TS17: facial ganglion Present Regionally restricted 3F Expression is in the nerve plexus that corresponds to a fusion of these ganglia.
TS17: trigeminal ganglion Present Regionally restricted 3F Expression is in the nerve plexus that corresponds to a fusion of these ganglia.
TS17: hindbrain Absent 3F

Specimen 5A: embryonic day 11.5; Egr2tm1Pch/Egr2+ (more )
Structure Level Pattern Image Note
TS19: acoustic ganglion Present 5A
TS19: cranial nerve Present 5A
TS19: facial ganglion Present 5A
TS19: trigeminal ganglion Present 5A

Specimen 5B: embryonic day 11.5; Egr2tm1Pch/Egr2tm1Pch (more )
Structure Level Pattern Image Note
TS19: acoustic ganglion Present 5B There are changes in morphology in cranial nerves and ganglia in this mutant.
TS19: cranial nerve Present 5B There are changes in morphology in cranial nerves and ganglia in this mutant.
TS19: facial ganglion Present 5B There are changes in morphology in cranial nerves and ganglia in this mutant.
TS19: trigeminal ganglion Present 5B There are changes in morphology in cranial nerves and ganglia in this mutant.

Specimen 5C: embryonic day 11.5; Egr2tm1Pch/Egr2+ (more )
Structure Level Pattern Image Note
TS19: cranial ganglion Present 5C
TS19: cranial nerve Present 5C

Specimen 5D: embryonic day 11.5; Egr2tm1Pch/Egr2tm1Pch (more )
Structure Level Pattern Image Note
TS19: cranial ganglion Present 5D There are changes in morphology in cranial nerves and ganglia in this mutant.
TS19: cranial nerve Present 5D There are changes in morphology in cranial nerves and ganglia in this mutant.

Specimen 7E: embryonic day 9.0; Egr2tm1Pch/Egr2+ (more )
Note: 11-13 somites
Structure Level Pattern Image Note
TS14: rhombomere 3 Present 7E
TS14: rhombomere 5 Present 7E

Specimen 7F: embryonic day 9.0; Egr2tm1Pch/Egr2tm1Pch (more )
Note: 11-13 somites
Structure Level Pattern Image Note
TS14: rhombomere 5 Present 7F


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory