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Gene Expression Data
Assay Details
Assay
Reference: J:181072 Kellermayer Z, et al., Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen. J Histochem Cytochem. 2011 Jul;59(7):690-700
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5800526
Gene symbol: Lyve1
Gene name: lymphatic vessel endothelial hyaluronan receptor 1
Antibody: anti-Mouse LYVE-1 MAb (Clone 223322)
Detection system: fluorescein
Results
Specimen 1C: postnatal; Nkx2-3tm1Hha/Nkx2-3tm1Hha (more )
Note: Double labeled: green - Lyve1; red - IBL-11 labeling of reticular fibroblasts.
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 1C Expression mainly in peripheral segment (upper part) without fibroblastic cuff.
Specimen 1D: postnatal (more )
Note: Double labeled: green - Lyve1; red - IBL-11 labeling of reticular fibroblasts.
Structure Level Pattern Image Note
TS28: spleen marginal zone Present Regionally restricted 1D Expression in platelets in marginal zone.
TS28: spleen red pulp Present Regionally restricted 1D Expression in megakaryocytes in red pulp.
TS28: spleen white pulp Absent 1D
Specimen 3E/G: postnatal (more )
Note: Double labeled: green - Lyve1; red - Kdr (assay MGI:5800530).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 3G , 3E Expression in sacs.
Specimen 4B: postnatal (more )
Note: Double labeled: green - Lyve1; red - Marco (assay MGI:5800533).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 4B Expression in sacs.
Specimen 4C: postnatal (more )
Note: Double labeled: green - Lyve1; red - Siglec1 (assay MGI:5800534).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 4C Expression in sacs.
Specimen 4D: postnatal (more )
Note: Double labeled: green - Lyve1; red - ER-TR7+ for fibroblastic reticular cell markers.
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 4D Expression in sacs.
Specimen 6A: embryonic day 18.5; Nkx2-3tm1Hha/Nkx2-3tm1Hha (more )
Note: Double labeled: green - Lyve1; blue - DAPI.
Structure Level Pattern Image Note
TS26: spleen Present Regionally restricted 6A
Specimen 6B: embryonic day 18.5 (more )
Note: Double labeled: green - Lyve1; blue - DAPI.
Structure Level Pattern Image Note
TS26: spleen Present Regionally restricted 6B
Specimen 6C: postnatal day 0.5; Nkx2-3tm1Hha/Nkx2-3tm1Hha (more )
Note: Double labeled: green - Lyve1; blue - DAPI.
Structure Level Pattern Image Note
TS27: spleen Present Regionally restricted 6C
Specimen 6D: postnatal day 0.5 (more )
Note: Double labeled: green - Lyve1; blue - DAPI.
Structure Level Pattern Image Note
TS27: spleen Present Regionally restricted 6D
Specimen 6E: postnatal day 10; Nkx2-3tm1Hha/Nkx2-3tm1Hha (more )
Note: Double labeled: green - Lyve1; blue - DAPI.
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 6E
Specimen 6F: postnatal day 10 (more )
Note: Double labeled: green - Lyve1; blue - DAPI.
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 6F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory