Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arhgef11tm1.1Mak
Name:	Rho guanine nucleotide exchange factor 11; targeted mutation 1.1, Tak Mak
MGI ID:	MGI:5788572
Synonyms:	PDZ-RhoGEF KO
Gene:	Arhgef11  Location: Chr3:87524866-87645341 bp, + strand  Genetic Position: Chr3, 38.22 cM
Alliance:	Arhgef11tm1.1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:233950
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site, followed by an FRT site, a neomycin selection cassette, a second loxP site and an FRT site are inserted upstream of exon 2, and a third loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2. Western blot and immunoblot analysis confirms that no protein was expressed in mutant mice. (J:233950)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arhgef11 Mutation:	75 strains or lines available

Original:	J:233950 Chang YJ, et al., The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes. Elife. 2015;4:e06011
All:	1 reference(s)